217184-95-7

Basic information

• Product Name: Proline, 4-hydroxy-, methyl ester (9CI)
• Synonyms: Proline, 4-hydroxy-, methyl ester (9CI)
• CAS NO: 217184-95-7
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.15644
• Product Categories: CARBOXYLICESTER;ALCOHOL
• Mol File: 217184-95-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Proline, 4-hydroxy-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 4-hydroxy-, methyl ester (9CI)(217184-95-7)
• EPA Substance Registry System: Proline, 4-hydroxy-, methyl ester (9CI)(217184-95-7)

Safety Data

• Hazardous Substances Data: 217184-95-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 51-35-4 3-hydroxy-dl-proline 
• 3398-22-9 trans-4-hydroxyproline 
• 81102-33-2 2-Benzyl-5-formyl-isoxazolidine-3-carboxylic acid methyl ester 
• 81102-35-4 2-Benzhydryl-5-formyl-isoxazolidine-3-carboxylic acid methyl ester 
• 81102-37-6 5-Formyl-2-(1-phenyl-propyl)-isoxazolidine-3-carboxylic acid methyl ester 

Downstream Products

• 51-35-4 3-hydroxy-dl-proline 

Relevant articles and documents

Comparison of liquid chromatography-isotope ratio mass spectrometry (LC/IRMS) and gas chromatography-combustion-isotope ratio mass spectrometry (GC/C/IRMS) for the determination of collagen amino acid δ13C values for palaeodietary and palaeoecological reconstruction

Results are presented of a comparison of the amino acid (AA) δ13C values obtained by gas chromatography-combustion-isotope ratio mass spectrometry (GC/C/IRMS) and liquid chromatography-isotope ratio mass spectrometry (LC/IRMS). Although the primary focus was the compound-specific stable carbon isotope analysis of bone collagen AAs, because of its growing application for palaeodietary and palaeoecological reconstruction, the results are relevant to any field where AA δ13C values are required. We compare LC/IRMS with the most up-to-date GC/C/IRMS method using N-acetyl methyl ester (NACME) AA derivatives. This comparison involves the analysis of standard AAs and hydrolysates of archaeological human bone collagen, which have been previously investigated as N-trifluoroacetyl isopropyl esters (TFA/IP). It was observed that, although GC/C/IRMS analyses required less sample, LC/IRMS permitted the analysis of a wider range of AAs, particularly those not amenable to GC analysis (e.g. arginine). Accordingly, reconstructed bulk δ13C values based on LC/IRMS-derived δ13C values were closer to the EA/IRMS-derived δ13C values than those based on GC/C/IRMS values. The analytical errors for LC/IRMS AA δ13C values were lower than GC/C/IRMS determinations. Inconsistencies in the δ13C values of the TFA/IP derivatives compared with the NACME- and LC/IRMS-derived δ13C values suggest inherent problems with the use of TFA/IP derivatives, resulting from: (i) inefficient sample combustion, and/or (ii) differences in the intra-molecular distribution of δ13C values between AAs, which are manifested by incomplete combustion. Close similarities between the NACME AA δ13C values and the LC/IRMS-derived δ13C values suggest that the TFA/IP derivatives should be abandoned for the natural abundance determinations of AA δ13C values.

UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION

The invention provides compounds urea-containing peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables T, R1-R9, J, L, M, Y, Z, m, n, and t are defined herein. Certain compounds of Formula

A Short-step Synthesis of 4-Hydroxyproline

The reaction of N-benzyl-, N-diphenylmethyl-, or N-(1-phenylpropyl)-α-methoxycarbonylmethanimine N-oxide newly prepared with acrylaldehyde in benzene, followed by hydrogenolysis over palladium hydroxide and by acid hydrolysis, gave 4-hydroxyprolines.