218610-57-2

Basic information

• Product Name: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene
• Synonyms: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene;2-(2,2,2-Trifluoroethoxy)bromobenzene
• CAS NO: 218610-57-2
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.0318496
• Mol File: 218610-57-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene(218610-57-2)
• EPA Substance Registry System: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene(218610-57-2)

Safety Data

• Hazardous Substances Data: 218610-57-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-bromo-2-(2,2,2-trifluoroethoxy)benzene is used as a reagent in various chemical reactions for the synthesis of other organic compounds. Its reactivity, due to the bromine atom, allows it to participate in a wide range of organic reactions, making it a valuable compound in the field of organic chemistry.
Used in Pharmaceutical Production:
1-bromo-2-(2,2,2-trifluoroethoxy)benzene serves as an intermediate in the production of pharmaceuticals. Its unique structure and reactivity enable the synthesis of various drug molecules, contributing to the development of new medications and therapies.
Used in Agrochemical Production:
In addition to pharmaceuticals, 1-bromo-2-(2,2,2-trifluoroethoxy)benzene is also utilized as an intermediate in the production of agrochemicals. Its applications in this industry help in the development of effective pesticides, herbicides, and other agricultural chemicals to improve crop yields and protect plants from pests and diseases.

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 75-89-8 2,2,2-trifluoroethanol 
• 1072-85-1 o-fluorobromobenzene 

Downstream Products

• 946605-58-9 C₁₈H₂₄F₃NO₄ 
• 957060-90-1 (2-(2,2,2-trifluoroethoxy)phenyl)boronic acid 
• 864754-11-0 4,4,5,5-tetramethyl-2-(2-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane 
• 790643-36-6 (4S)-4-(3,4-Difluorophenyl)-6-methoxymethyl-2-oxo-3-(2-(1-(2-(2,2,2-trifluoroethoxy)phenyl)piperidin-4-ylamino)ethylcarbamoyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester 
• 218610-61-8 (2-(1-(2-(2,2,2-Trifluoroethoxy)phenyl)piperidin-4-ylamino)ethyl)-carbamic acid tert-butyl ester 
• 218610-62-9 N₁-(1-(2-(2,2,2-Trifluoroethoxy)phenyl)piperidin-4-yl)ethane-1,2-diamine 
• 218610-59-4 N-(o-(2,2,2-Trifluoroethoxy)phenyl)-4-piperidone 
• 1426801-83-3 C₂₄H₂₁ClF₃NO₄S 
• 910605-42-4 3,4-dimethoxy-N-trans-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide 
• 910605-41-3 3,4-dimethoxy-N-cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide 
• 946605-81-8 4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine 
• 910605-45-7 (4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester 
• 946605-74-9 4-[4-(2-cyclopropoxy-phenyl)-piperidin-1-yl]-cyclohexylamine 

Relevant articles and documents

(2, 2, 2 - trifluoroethoxy) phenyl boronic acid synthetic method of compound (by machine translation)

The invention discloses a (2, 2, 2 - trifluoroethoxy) phenyl boronic acid compound synthesis method. In order to O bromine monofluoro-benzene and its derivative as the starting material, in the alkaline conditions and trifluoro ethanol produced by the reaction of 1 - bromo - 2 - (2, 2, 2 - trifluoroethoxy) benzene and its derivatives, to obtain the product of the metal reagent under the action of the borate reaction to obtain the type III compound 2 - (2, 2, 2 - trifluoroethoxy) phenyl boronic acid and its derivatives. The synthesis route is relatively short, low cost, easy to operate, the yield is high. Can be used for the production of industrial expansion. (by machine translation)

(Phenylpiperidinyl)cyclohexylsulfonamides: Development of α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)

Although α1 adrenergic receptor blockers can be very effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), their usage is limited by CV-related side-effects that are caused by the subtype non-selec

BIARYL SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant com

Alpha 1a adrenergic receptor antagonists

This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.