21883-61-4

Basic information

• Product Name: 2-phenylvaline
• CAS NO: 21883-61-4
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 21883-61-4.mol

Chemical Properties

• Boiling Point: 319.1°C at 760 mmHg
• Flash Point: 146.8°C
• Density: 1.128g/cm³
• Vapor Pressure: 0.000144mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 2-phenylvaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylvaline(21883-61-4)
• EPA Substance Registry System: 2-phenylvaline(21883-61-4)

Safety Data

• Hazardous Substances Data: 21883-61-4(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 78-84-2 isobutyraldehyde 
• 62-53-3 aniline 
• 74-90-8 hydrogen cyanide 
• 591-50-4 iodobenzene 
• 516-06-3 D,L-valine 
• 108-86-1 bromobenzene 
• 10323-40-7 2-bromoisovaleric acid 
• 609-12-1 ethyl 2-bromoisovalerate 

Downstream Products

• 69409-71-8 3'-phenoxybenzyl α-isopropylanilinoacetate 
• 1224467-07-5 N-phenyl-L-valine-L-phenylalanine methyl ester 
• 13328-73-9 4-isopropyl-2-methyl-2,3-diphenyl-[1,3,2]oxazasilolidin-5-one 

Relevant articles and documents

Integrated Flow Synthesis of α-Amino Acids byIn SituGeneration of Aldimines and Subsequent Electrochemical Carboxylation

The synthesis of α-amino acids was carried out in a continuous flow system. In this system, aldimines were efficiently generatedin situvia the dehydration-condensation of aldehydes with anilines in a desiccant bed column filled with 4 ? molecular sieves d

Use of diphenyliodonium bromide in the synthesis of some N-phenyl-amino acids

The N-phenyl methyl esters 4 of glycine, alanine, valine, leucine, isoleucine, phenylalanine, methionine, proline, serine, threonine, tyrosine, aspartic acid, and glutamic acid have been synthesized in good to excellent yields using diphenyliodonium bromide, AgNO3, and a catalytic amount of CuBr starting from the relevant amino acid ester. The chiral integrity of the amino acids 5 was maintained during these reactions, which were confirmed by the synthesis of dipeptide for each N-phenyl amino acid. The structures of the new compounds were confirmed by the analysis of their IR, 1H, and 13C NMR spectra in addition to CHN microanalysis or high-resolution mass spectrometry for the new N-phenyl amino acids 5 and the esters 4.

A mild and efficient method for copper-catalyzed Ullmann-type N-arylation of aliphatic amines and amino acids

An efficient and general protocol for copper-catalyzed N-arylation of aliphatic amines and amino acids has been developed using aryl iodides under mild conditions (coupling temperature at 25-35°C). For the N-(o-nitrophenyl) amino acid derivatives, subsequent reduction of the nitro group in the presence of tin(II) chloride resulted in 3,4-dihydroquinoxalin-2(1H)-one derivatives in good yields. Georg Thieme Verlag Stuttgart New York.

Copper-catalyzed aryl amination in aqueous media with 2- dimethylaminoethanol ligand

Copper-catalyzed amination of aryl bromides and iodides under mild conditions has been developed with 2-dimethylaminoethanol as ligand and water as solvent. A variety of hydrophilic and hydrophobic aryl halide substrates have been aminated in good yield with a variety of amino acids, amino alcohols and peptides. This method has successfully N-arylated some hydrophilic amino compounds not available by other methods.

Synthesis and Characterization of N-Substituted Valines and their Phenyl- and Pentafluorophenyl-thiohydantoins

The phenylthiohydantoins of racemic N-methyl-, N-(2-hydroxethyl)- and N-phenyl-valine as well as the pentafluorophenylthiohydantoins of these acids and of L-valine have been synthesized by reactions with phenyl isothiocynate and pentafluorophenyl isothioc