220270-61-1

Basic information

• Product Name: Ethanone, 2-bromo-1-(5-methyl-2-thiazolyl)- (9CI)
• Synonyms: Ethanone, 2-bromo-1-(5-methyl-2-thiazolyl)- (9CI)
• CAS NO: 220270-61-1
• Molecular Formula: C₆H₆BrNOS
• Molecular Weight: 220.08694
• Product Categories: ACETYLHALIDE
• Mol File: 220270-61-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2-bromo-1-(5-methyl-2-thiazolyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-(5-methyl-2-thiazolyl)- (9CI)(220270-61-1)
• EPA Substance Registry System: Ethanone, 2-bromo-1-(5-methyl-2-thiazolyl)- (9CI)(220270-61-1)

Safety Data

• Hazardous Substances Data: 220270-61-1(Hazardous Substances Data)

Upstream product

• 59303-17-2 1-(5-methylthiazol-2-yl)ethan-1-on 
• 3581-89-3 5-methylthiazole 
• 96-32-2 bromoacetic acid methyl ester 

Relevant articles and documents

SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS

The invention pertains to heteroaromatic compounds of the formula I, as defined herein, that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

Indole compounds as COX-2 inhibitors

This invention provides a compound of the following formula: and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; Y is a direct bond or C1-4alkylidene; Q is C1-6alkyl, C3-7cycloalkyl, phenyl, naphthyl, heteroaryl or the like; R1is hydrogen, C1-6alkyl or the like; R2is hydrogen, C1-4alkyl, C(O)R5wherein R5is C1-22alkyl or C2-22alkenyl, halosubstituted C1-8alkyl, halosubstituted C2-8alkenyl, —Y—C3-7cycloalkyl, —Y—C3-7cycloalkenyl, phenyl, naphthyl, heteroaryl or the like; X is halo, C1-4alkyl, hydroxy, C1-4alkoxy or the like; and n is 0, 1, 2 or 3, with the proviso that a group of formula —Y—Q is not methyl or ethyl when X is hydrogen; L is oxygen; R1is hydrogen; and R2is acetyl. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is tetrazolyl optionally substituted with a substituent selected from C1-4 alkyl and halosubstituted C1-4 alkyl;A is C1-6 alkylene; Q is selected from the following groups: (a) optionally substituted phenyl; (b) an optionally substituted, partially saturated, fully saturated or fully unsaturated five to six membered monocyclic group having one to three heteroatoms; and (c) an optionally substituted, bicyclic group consisting of two fused partially saturated, fully saturated or fully unsaturated five or six membered rings independently and optionally having one to four heteroatoms; X is halogen, C1-4 alkyl, halosubstituted C1-4 alkyl, OH, C1-4 alkoxy or the like; and n is 0, 1, 2, 3 or 4. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.