220898-16-8

Basic information

• Product Name: tert-Butyl 5-oxo-7-phenyl-1,4-diazepane-1-carboxylate
• Synonyms: tert-Butyl 5-oxo-7-phenyl-1,4-diazepane-1-carboxylate;tert-Butyl5-oxo-7-phenylhomopiperazine-1-carboxylate
• CAS NO: 220898-16-8
• Molecular Formula: C₁₆H₂₂N₂O₃
• Molecular Weight: 290.35748
• Mol File: 220898-16-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 5-oxo-7-phenyl-1,4-diazepane-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 5-oxo-7-phenyl-1,4-diazepane-1-carboxylate(220898-16-8)
• EPA Substance Registry System: tert-Butyl 5-oxo-7-phenyl-1,4-diazepane-1-carboxylate(220898-16-8)

Safety Data

• Hazardous Substances Data: 220898-16-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 89044-79-1 7-phenyl hexahydro-1,4-diazepine-5-one 
• 57552-95-1 7-phenyl-1,2,3,4-tetrahydro-1,4-diazepin-5-one 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 220898-23-7 1-tert-butoxycarbonyl-7-phenyl-1,4-diazepane 
• 1268830-15-4 4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane 
• 1268830-23-4 1-benzoyl-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-24-5 1-(2,4-dichlorobenzoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-25-6 1-(2-biphenoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-26-7 1-(1-naphthoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-27-8 1-cyclohexanoyl-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-28-9 1-(1-adamantanoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-29-0 1-benzoyl-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-30-3 1-(2,4-dichlorobenzoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-31-4 1-(2-biphenoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-32-5 1-(1-naphthoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-33-6 1-cyclohexanoyl-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-34-7 1-(1-adamantanoyl)-5-phenyl-1,4-diazepane hydrochloride 

Relevant articles and documents

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer

A new class of potent farnesyltransferase inhibitors based on a 1,4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostati

Synthesis of 1,4-diazepin-5-ones under microwave irradiation and their reduction products

A new efficient access to 1,4-diazepane derivatives is described via a microwave assisted synthesis of 7-substituted-1,4-diazepin-5-ones, which proceeds rapidly in good yields. Catalytic reduction gave 1,4-diazepan-5-ones and 1,4-diazepanes whereas a ring

7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them

Neurokinin-antagonistic compounds corresponding to formula I: in which R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R2 and R3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R4 and R5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R6 is lower alkyl, halogen or trifluoromethyl, R7 is lower alkyl, halogen or trifluoromethyl, A is a -(CH2)n- group in which n represents an integer from 1 to 3, or an -NH-(CH2)m- group in which m represents an integer from 2 to 3, and B is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl, and physiologically acceptable salts thereof and processes for the preparation of these compounds.