57552-95-1

Usage

Uses

Used in Pharmaceutical Research:
5H-1,4-Diazepin-5-one, 1,2,3,4-tetrahydro-7-phenylis used as a building block for the synthesis of bioactive compounds due to its unique structure and properties. It serves as a precursor in the development of new pharmaceutical agents with potential therapeutic applications.
Used in Drug Development:
5H-1,4-Diazepin-5-one, 1,2,3,4-tetrahydro-7-phenylis used as a potential drug candidate in the pharmaceutical industry. Its structure and properties make it suitable for further exploration and optimization to develop new drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
5H-1,4-Diazepin-5-one, 1,2,3,4-tetrahydro-7-phenylis utilized as a key intermediate in organic synthesis, particularly for the preparation of complex organic molecules and pharmaceutical agents. Its versatile chemical reactivity allows for the formation of various derivatives with diverse biological activities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5H-1,4-Diazepin-5-one, 1,2,3,4-tetrahydro-7-phenyl- is employed for the design and synthesis of novel therapeutic agents targeting specific biological pathways and receptors. Its unique structural features enable the development of drugs with enhanced selectivity and potency.
Used in Chemical Libraries:
5H-1,4-Diazepin-5-one, 1,2,3,4-tetrahydro-7-phenylis incorporated into chemical libraries for high-throughput screening and drug discovery. Its presence in these libraries allows researchers to evaluate its potential as a lead compound and identify novel bioactive molecules with therapeutic potential.

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 107-15-3 ethylenediamine 
• 98-86-2 acetophenone 
• 1006-67-3 5-phenylisoxazole 

Downstream Products

• 130017-21-9 7-phenyl-2,3,4,5-tetrahydro-1,4-diazepine-5-thione 
• 89044-79-1 7-phenyl hexahydro-1,4-diazepine-5-one 
• 150254-24-3 6-chloro-7-phenyl-2,3,4,5-tetrahydro-1,4-diazepine-5-one 
• 1268937-57-0 1-(1-adamantanoyl)-4-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane 
• 1268830-44-9 1-cyclohexanoyl-4-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane dihydrochloride 
• 1268937-56-9 1-(1-naphthoyl)-4-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane 
• 1268937-55-8 1-(2-biphenoyl)-4-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane 
• 1268937-54-7 1-(2,4-dichlorobenzoyl)-4-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-methyl}-5-phenyl-1,4-diazepane 
• 1268937-53-6 1-benzoyl-4-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane 
• 1268830-34-7 1-(1-adamantanoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-33-6 1-cyclohexanoyl-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-32-5 1-(1-naphthoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-31-4 1-(2-biphenoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-30-3 1-(2,4-dichlorobenzoyl)-5-phenyl-1,4-diazepane hydrochloride 

Relevant academic research and scientific papers

Synthesis, X-ray, spectroscopic characterization, Hirshfeld surface analysis, DFT calculation and molecular docking investigations of a novel 7-phenyl-2,3,4,5-tetrahydro-1H-1,4- diazepin-5-one derivative

The tetrahydrodiazepine ring in the title molecule, C11H12N2O, adopts a twisted envelope conformation. In the crystal, inversion dimers are formed by N[sbnd]H?O hydrogen bonds which are connected into corrugated layers by

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer

A new class of potent farnesyltransferase inhibitors based on a 1,4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostati

DIAZEPINE DERIVATIVES AS 5-HT2A ANTAGONISTS

Compounds of formula I: are selective 5HT2A antagonists and hence find use in treatment or prevention of a variety of CNS disorders.

Synthesis of 1,4-diazepin-5-ones under microwave irradiation and their reduction products

A new efficient access to 1,4-diazepane derivatives is described via a microwave assisted synthesis of 7-substituted-1,4-diazepin-5-ones, which proceeds rapidly in good yields. Catalytic reduction gave 1,4-diazepan-5-ones and 1,4-diazepanes whereas a ring

Synthesis and pharmacological study of 7-phenyl-1,4-diazepin-5-one and its derivatives

We studied the synthesis and psychotropic activity of the 7-phenyl-1,4-diazepin-5-one and derivatives. It can be conclude that these products have sedative, myorelaxant and anxiolytic actions. The toxicity study demonstrated that two diazepines are non-to

ETUDE DE LA REACTIVE DE LA 7-PHENYL-1,4-DIAZEPINE-5-ONE

The reactivity of 7-phenyl-1,4-diazepin-5-one has been described.The new compounds obtained have been characterized by 1H NMR, IR, MS and microanalysis.

5-Pyrrolidino, piperidino or N'-2-hydroxyethylpiperazino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines

Compounds of the formula STR1 wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms or amino, R2 is hydrogen or alkyl of 1 to 6 carbon atoms, with the provisos that (1) at least one of R1 and R2 is not a tertiary

5-Amino or substituted amino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines

Compounds of the formula STR1 wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms or amino, R2 is hydrogen or alkyl of 1 to 6 carbon atoms, with the provisos that (1) at least one of R1 and R2 is not a tertiary

5-Amino or substituted amino-7-phenyl or substituted phenyl-2,3-dihydro-1H-1,4-diazepines

Compounds of the formula STR1 WHEREIN R1 is hydrogen, alkyl of 1 to 6 carbon atoms or amino, R2 is hydrogen or alkyl of 1 to 6 carbon atoms, with the provisos that (1) at least one of R1 and R2 is not a tertiary