220939-72-0

Basic information

• Product Name: 3-Bromo-4-chlorofuro[3,2-c]pyridine
• Synonyms: 3-Bromo-4-chlorofuro[3,2-c]pyridine
• CAS NO: 220939-72-0
• Molecular Formula: C₇H₃BrClNO
• Molecular Weight: 232.464
• Product Categories: Heterocycle-Pyridine series
• Mol File: 220939-72-0.mol

Chemical Properties

• Boiling Point: 305.519°C at 760 mmHg
• Flash Point: 138.573°C
• Appearance: /
• Density: 1.82g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Bromo-4-chlorofuro[3,2-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-chlorofuro[3,2-c]pyridine(220939-72-0)
• EPA Substance Registry System: 3-Bromo-4-chlorofuro[3,2-c]pyridine(220939-72-0)

Safety Data

• Hazardous Substances Data: 220939-72-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4-chlorofuro[3,2-c]pyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved therapeutic properties. Its unique structure allows for the creation of compounds that can target specific biological pathways, potentially leading to more effective treatments for a range of diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-4-chlorofuro[3,2-c]pyridine is employed as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Research and Development:
3-Bromo-4-chlorofuro[3,2-c]pyridine is utilized as a valuable precursor in the research and development of new compounds with potential medicinal and agricultural applications. Its unique chemical properties make it an attractive candidate for the exploration of novel chemical entities that can address unmet needs in these fields.

InChI:InChI=1/C7H3BrClNO/c8-4-3-11-5-1-2-10-7(9)6(4)5/h1-3H

Upstream product

• 220939-57-1 3-bromo-furo[3,2-c]pyridine 5-oxide 
• 31270-80-1 4-chlorofuro[3,2-c]pyridine 
• 92404-70-1 3-bromofuro<3,2-c>pyridine 
• 29080-01-1 β-(2-Furan)-vinylisocyanat 
• 539-47-9 3-(2-furyl)acrylic acid 
• 26956-43-4 5H-furo[3,2-c]pyridin-4-one 
• 59898-36-1 (E)-3-Furan-2-yl-acryloyl azide 
• 98-01-1 furfural 

Downstream Products

• 799293-74-6 4-amino-3-(4-aminophenyl)-furo[3,2-c]pyridine 
• 799293-76-8 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-furo[3,2-c]pyridine 
• 799293-78-0 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-7-bromo-furo[3,2-c]pyridine 
• 1609581-30-7 3-bromo-4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]furo[3,2-c]pyridine 
• 1571111-34-6 6-(4-aminofuro[3,2-c]pyridin-3-yl)-N-phenyl-1-naphthalenecarboxamide 
• 799293-73-5 3-bromofuro[3,2-c]pyridin-4-ylamine 

Relevant articles and documents

Furopyridines. XXVIII. Reactions of 3-bromo derivatives of furo[2,3-b]- , -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine and their N-oxides

Bromination of 3-bromofuro[2,3-b]- 1a, -[3,2-b]- lb and - [3,2- c]pyridine ld afforded the 2,3-dibromo derivatives 2a, 2b and 2d, while the - [2,3-c]- compound lc did not give the dibromo derivative. Nitration of 1a-d gave the 2-nitro-3-bromo compounds 3a-d. The N-oxides 4a-d of 1a-d were submitted to the cyanation with trimethylsilyl cyanide to yield the corresponding α-cyanopyridine compound 6a-d. Chlorination of 4a and 4d with phosphorus oxychloride gave mainly the chloropyridine derivatives 7a, 7'a and 7d, while 4b and 4c gave mainly the chlorofuran derivatives 7(b) and 7(c) accompanying formation of the chloropyridine derivatives 7b, 7'b and 7c. Acetoxylation of 4a and 4b with acetic anhydride yielded the acetoxypyridine compounds 8a, 8'a and 8b, while 4c and 4d gave the acetoxypyridine 8'c, 8'd and 8(d), pyridone 8c and 8d, acetoxyfuran 8(c) and dibromo compound 9c and 9'c.

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for treating and preventing tumors ans cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.