221393-16-4Relevant articles and documents
Synthesis method of 1, 2, 4-oxadiazole-3, 5-diketone
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Paragraph 0035-0039; 0041-0043; 0045-0047, (2021/08/19)
The invention relates to a synthesis method of 1, 2, 4-oxadiazole-3, 5-diketone. The method comprises the following steps: placing a reaction mixed solution of a compound 1 and an alkali solution in a reaction system, adding an oxidizing agent, reacting for a period of time, adjusting the pH to be acidic, performing filtering, and recrystallizing a filter cake to obtain a compound 2; and placing the compound 2, an inorganic solvent and an organic solvent in a reaction system, adding nitrite for a reaction, and after the reaction is finished, performing filtering and recrystallization to obtain the target compound 1, 2, 4-oxadiazole-3, 5-diketone. According to the method, the raw materials are few in variety and easy to obtain; reaction conditions are mild; compared with a synthesis method in the literature 2, the provided method has less three-waste emission and fewer steps; and hydroxylamine is used in the literature 2, and the requirement for equipment in industrial production is strict, while the hydroxylamine does not need to be used in the method, the process is simple, and the requirement for the equipment is low.
Synthetic and tautomeric studies of 5-amino-2,3-dihydro-1,2,4-oxadiazol-3-one
Ra, Do Young,Cho, Nam Sook,Kang, Sung Kwon,Choi, Eun Suk,Suh, Il Hwan
, p. 81 - 84 (2007/10/03)
5-Amino-2,3-dihydro-1,2,4-oxadiazol-3-one 2 was synthesized as an analogue of cytosine. Among the possible four tautomers it was established by spectroscopic methods and ab initio calculations that it exists as a lactam form 2b like cytosine. The NH is more acidic than NH2, thus it could be regioselectively mesylated and acetylated under basic conditions.
