- PANTETHEINE DERIVATIVES AND USES THEREOF
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The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
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Paragraph 2121
(2020/06/19)
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- Preparation of some alkenoic acid derivatives as new plant growth regulators
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A number of 3-alkoxy-5-substituted-2,4-alkadienoic acids (4a-f) have been synthesized from the reaction of ethyl (E)-3-alkoxy-2-butenoate with different ketones in the presence of KOH in DMSO. Similarly, several (2Z,4E)-5-[4-(benzylthio)phenyl]-3-alkoxyhe
- Abu Safieh, Kayed A.,Hasan, Ala'A K.,Ayoub, Mikdad T.,Mubarak, Mohammad S.
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p. 1863 - 1872
(2015/03/18)
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- Iron(III) tosylate in the preparation of dimethyl and diethyl acetals from ketones and β-keto enol ethers from cyclic β-diketones
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An efficient method for conversion of ketones to their corresponding dimethyl and diethyl acetals and of cyclic β-diketones into β-keto enol ethers using Fe(OTs)3 as a catalyst is described. Copyright Taylor & Francis Group, LLC.
- Mansilla, Horacio,Afonso, Maria M.
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p. 2607 - 2618
(2008/12/22)
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- Iridium-catalyzed asymmetric hydrogenation of vinyl ethers
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A carbene-oxazoline catalyst 1 proved to be an effective catalyst for reduction of an enol ether that the literature suggested could not be hydrogenated effectively by P,N-Ir catalysts. Thus, a series of ester and alcohol substrates were hydrogenated using catalyst 1. Good to excellent enantioselectivities and high conversions were obtained.
- Zhu, Ye,Burgess, Kevin
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supporting information; experimental part
p. 979 - 983
(2009/05/30)
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- New insights into the reduction of β,δ-diketo-sulfoxides
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New developments in the reduction of β,δ-diketo-sulfoxides, a reaction that affords important key intermediates for total synthesis, are described. We showed without ambiguity using NMR experiments, that the β-carbonyl group is totally enolised. This result is inconsistent with the previous hypothesis, which supposed the other tautomer (enolisation at the δ-position) as the major one. We propose a rationale to explain the side reactions occurring during the reduction of unprotected β,δ-diketo-sulfoxides and showed that judicious protection of the δ-carbonyl group gave all diastereoisomers of β-hydroxy-δ-ketosulfoxides.
- Hanquet, Gilles,Salom-Roig, Xavier J.,Gressot-Kempf, Laurence,Lanners, Steve,Solladie, Guy
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p. 1291 - 1301
(2007/10/03)
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- Carboxy(vinyl)ketene intermediates in the thermolysis of methylthio- and methoxy-substituted Meldrum's acid derivatives
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Methylthio- and methoxy-substituted carboxy(vinyl)ketenes 10 and 16a have been identified by Ar matrix isolation FTIR spectroscopy following flash vacuum thermolysis (FVT) of Meldrum's acid derivatives 7 and 13a. Methylthio(methyl)methyleneketene 9 and alkoxy(methyl)methyleneketene 15 are formed concurrently at high FVT temperatures. The alkoxy(methyl)methyleneketenes 15 do not isomerise to alkoxy(vinyl)ketenes 18, which have been generated and identified in other reactions. Ethoxy(methyl)-methyleneketene 15b readily eliminates ethene in a retro-ene type reaction to produce acetylketene 22. Ketenes 15 react with alcohols and amines to produce 3-alkoxybutenoic acid derivatives 21.
- Bibas, Herve,Kappe, C. Oliver,Wong, Ming Wah,Wentrup, Curt
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p. 493 - 498
(2007/10/03)
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- Reaction of Ethyl (E)-3-Methoxy-2-butenoate with Some Substituted Aromatic Aldehydes: Synthesis of 5-Aryl-3-Methoxy-(2E,4E)-2,4-Pentadienoic Acids
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The reaction between ethyl (E)-3-methoxy-2-butenoate (1) and some substituted benzaldehydes 2 in the presence of sodium hydride leads to 5-aryl-3-methoxy-(2E,4E)-2,4-pentadienoic acids 3.The UV, IR and (1)H- and (13)C-NMR spectral data for the compounds s
- Ayoub, Mikdad T.,Shandala, Mowafk Y.,Jafar, Abdul W.
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p. 653 - 655
(2007/10/02)
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- RETINOIDE-II : DARSTELLUNG VON 13-METHOXYRETINAL
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9-trans-13-cis-(7a) and 9-cis-13-cis-13-Methoxyretinal (7b) have been prepared from the C15-aldehyde 5 and the E-phosphonate 4 by Wittig-Horner reaction.
- Natsias, Konstantin,Hopf, Henning
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p. 3673 - 3676
(2007/10/02)
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