22200-47-1Relevant articles and documents
Synthesis of novel anilinoquinolines as c-fms inhibitors
Smalley Jr., Terrence L.,Chamberlain, Stanley D.,Mills, Wendy Y.,Musso, David L.,Randhawa, Sab A.,Ray, John A.,Samano, Vicente,Frick, Lloyd
, p. 6257 - 6260 (2007)
A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable analog suitable for further investigative work.
Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate
Horta,Henriques,Ku?,Paix?o,O'Neill,Cristiano,Fausto
, p. 7583 - 7592 (2015/09/07)
In this work, we report the synthesis of a novel quinoline derivative, ethyl 4-chloro-7-iodoquinoline-3-carboxylate (CIQC), and its structural, conformational and vibrational characterization. The compound was studied in its neat solid phases (crystalline
HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 266-267, (2009/12/28)
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
Compounds and Methods of Treatment
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Page/Page column 12, (2008/12/08)
A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.
NOVEL QUINOLINE DERIVATIVES
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Page/Page column 52, (2008/06/13)
The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS
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Page/Page column 54, (2010/02/13)
The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.
Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines
De, Dibyendu,Krogstad, Frances M.,Byers, Larry D.,Krogstad, Donald J.
, p. 4918 - 4926 (2007/10/03)
Aminoquinolines (AQs) with diaminoalkane side chains (-HNRNEt2) shorter or longer than the isopentyl side chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -resistant Plasmodium falciparum. (De, D.; et al. Am. J. Trop. Med. Hyg. 1996, 55, 579-583). In the studies reported here, we examined structure-activity relationships (SARs) among AQs with different N,N-diethyldiaminoalkane side chains and different substituents at the 7-position occupied by Cl in chloroquine. 7-Iodo- and 7- bromo-AQs with diaminoalkane side chains [-HN(CH2)2NEt2, -HN(CH2)3NEt2, or -HNCHMeCH2NEt2] were as active as the corresponding 7-chloro-AQs against both chloroquine-susceptible and -resistant P. falciparum (IC50s of 3-12 nM). In contrast, with one exception, 7-fluoro-AQs and 7-trifluoromethyl-AQs were less active against chloroquine-susceptible P. falciparum (IC50s of 15-50 nM) and substantially less active against chloroquine-resistant P. falciparum (IC50s of 18-500 nM). Furthermore, most 7-OMe-AQs were inactive against both chloroquine-susceptible (IC50s of 17-150 nM) and -resistant P. falciparum (IC50s of 90-3000 nM).
