22297-71-8

Usage

Uses

Used in Pharmaceutical Applications:
4-HYDROXY-7-IODOQUINOLINE is used as an antimalarial agent for treating parasitic infections. It is known for its potential therapeutic effects against malaria, a disease caused by Plasmodium parasites.
Used in Antimicrobial Applications:
4-HYDROXY-7-IODOQUINOLINE is also studied for its potential antimicrobial properties, indicating its use in combating various types of microbial infections.
Used in Organic Synthesis:
4-HYDROXY-7-IODOQUINOLINE serves as a reagent in organic synthesis, playing a crucial role in the preparation of other chemical compounds.
Used in Chemical Industry:
In the chemical industry, 4-HYDROXY-7-IODOQUINOLINE is utilized in the preparation of various chemical compounds, contributing to the development of new products and materials.

InChI:InChI=1/C9H6INO/c10-6-1-2-7-8(5-6)11-4-3-9(7)12/h1-5H,(H,11,12)

Upstream product

• 22200-49-3 4-hydroxy-7-iodo-quinoline-3-carboxylic acid 
• 134785-83-4 4-hydroxy-7-iodo-quinoline-2-carboxylic acid 
• 626-01-7 3-Iodoaniline 
• 1062589-61-0 C₁₀H₆INO₃ 
• 153952-04-6 4-hydroxy-7-iodo-quinoline-2-carboxylic acid ethyl ester 
• 22200-47-1 diethyl 2-(((3-iodophenyl)amino)methylene)malonate 
• 22200-48-2 4-hydroxy-7-iodo-quinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 22200-50-6 4-chloro-7-iodoquinoline 
• 17127-81-0 4-(3-Dimethylaminopropylamino)-7-iodchinolin 
• 81764-16-1 4-chloro-8-aminoquinoline 
• 1450909-21-3 (1-benzyl-7-trimethylstannanyl-1H-quinolin-4-ylidene)-pentyl-amine 
• 1450909-20-2 (1-benzyl-7-iodo-1H-quinolin-4-ylidene)-pentyl-amine 

Relevant academic research and scientific papers

Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels

In vivo imaging of voltage-gated sodium channels (VGSCs) can potentially provide insights into the activation of neuronal pathways and aid the diagnosis of a number of neurological diseases. The iminodihydroquinoline WIN17317-3 is one of the most potent s

Compounds and Methods of Treatment

A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.

NOVEL QUINOLINE DERIVATIVES

The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).

Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines

Aminoquinolines (AQs) with diaminoalkane side chains (-HNRNEt2) shorter or longer than the isopentyl side chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -resistant Plasmodium falciparum. (De, D.; et al. Am. J. Trop. Med. Hyg. 1996, 55, 579-583). In the studies reported here, we examined structure-activity relationships (SARs) among AQs with different N,N-diethyldiaminoalkane side chains and different substituents at the 7-position occupied by Cl in chloroquine. 7-Iodo- and 7- bromo-AQs with diaminoalkane side chains [-HN(CH2)2NEt2, -HN(CH2)3NEt2, or -HNCHMeCH2NEt2] were as active as the corresponding 7-chloro-AQs against both chloroquine-susceptible and -resistant P. falciparum (IC50s of 3-12 nM). In contrast, with one exception, 7-fluoro-AQs and 7-trifluoromethyl-AQs were less active against chloroquine-susceptible P. falciparum (IC50s of 15-50 nM) and substantially less active against chloroquine-resistant P. falciparum (IC50s of 18-500 nM). Furthermore, most 7-OMe-AQs were inactive against both chloroquine-susceptible (IC50s of 17-150 nM) and -resistant P. falciparum (IC50s of 90-3000 nM).

Thioquinolone compounds which have useful pharmaceutical activity

Disclosed is a thioquinolone derivative which exhibits highly selective antibacterial activity against Helicobacter pylori.