22200-50-6

Basic information

• Product Name: 7-IODO-4-CHLOROQUINOLINE
• Synonyms: 7-IODO-4-CHLOROQUINOLINE;BUTTPARK 89\09-06
• CAS NO: 22200-50-6
• Molecular Formula: C₉H₅ClIN
• Molecular Weight: 289.5
• Mol File: 22200-50-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 101-102 °C
• Boiling Point: 338.368 °C at 760 mmHg
• Flash Point: 158.439 °C
• Appearance: /
• Density: 1.92 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.05±0.27(Predicted)
• CAS DataBase Reference: 7-IODO-4-CHLOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-IODO-4-CHLOROQUINOLINE(22200-50-6)
• EPA Substance Registry System: 7-IODO-4-CHLOROQUINOLINE(22200-50-6)

Safety Data

• Hazardous Substances Data: 22200-50-6(Hazardous Substances Data)

Usage

General Description

7-Iodo-4-chloroquinoline is a chemical compound with the molecular formula C9H5ClIN. It is a halogenated quinoline derivative that is commonly used in the synthesis of pharmaceutical compounds, particularly antimalarial drugs. 7-IODO-4-CHLOROQUINOLINE has been studied for its potential antiparasitic and antimicrobial properties due to its ability to inhibit the growth of Plasmodium species, the parasites that cause malaria. Additionally, it has been investigated for its potential use in the treatment of other infectious diseases. 7-Iodo-4-chloroquinoline is a versatile building block in organic synthesis and has been utilized in the development of various bioactive compounds with potential therapeutic applications. Its unique chemical structure and pharmacological properties make it an important compound in the field of drug discovery and development.

InChI:InChI=1/C9H5ClIN/c10-8-3-4-12-9-5-6(11)1-2-7(8)9/h1-5H

Upstream product

• 22297-71-8 7-iodo-quinolin-4-ol 
• 626-01-7 3-Iodoaniline 
• 153952-04-6 4-hydroxy-7-iodo-quinoline-2-carboxylic acid ethyl ester 
• 134785-83-4 4-hydroxy-7-iodo-quinoline-2-carboxylic acid 
• 22200-47-1 diethyl 2-(((3-iodophenyl)amino)methylene)malonate 
• 22200-48-2 4-hydroxy-7-iodo-quinoline-3-carboxylic acid ethyl ester 
• 22200-49-3 4-hydroxy-7-iodo-quinoline-3-carboxylic acid 

Downstream Products

• 17127-81-0 4-(3-Dimethylaminopropylamino)-7-iodchinolin 
• 231277-94-4 (4-phenoxyphenyl)-(7-((4-(2-methanesulphonyl)ethylaminomethyl)thiazol-5-yl)-quinolin-4-yl)amine 
• 1450909-21-3 (1-benzyl-7-trimethylstannanyl-1H-quinolin-4-ylidene)-pentyl-amine 
• 1450909-20-2 (1-benzyl-7-iodo-1H-quinolin-4-ylidene)-pentyl-amine 
• 1062589-83-6 C₁₅H₉ClFIN₂O*ClH 
• 1062751-74-9 C₁₅H₉ClFIN₂O 
• 1062589-64-3 C₁₄H₉ClN₂ 
• 81764-16-1 4-chloro-8-aminoquinoline 

Relevant articles and documents

Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels

In vivo imaging of voltage-gated sodium channels (VGSCs) can potentially provide insights into the activation of neuronal pathways and aid the diagnosis of a number of neurological diseases. The iminodihydroquinoline WIN17317-3 is one of the most potent s

NOVEL QUINOLINE DERIVATIVES

The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).

SYNTHESIS OF DERIVATIVES OF 7-IODO-4-AMINOQUINOLINES

7-Iodo- and 7,8-diiodo-4-(3-dimethylaminopropylamino)quinolines and 7-iodo-4-(3-dipropylaminopropylamino)- and 7-iodo-4-(3-diallylaminopropylamino)quinoline were obtained by the reaction of 7-iodo- and 7,8-diiodo-4-chloroquinolines with the the corresponding diamines.The catalytic hydrogenation of 7-iodo-4-(3-diallylaminopropylamino)quinoline at normal pressure leads to 7-iodo-4-(3-dipropylaminopropylamino)quinoline.