222180-20-3

Basic information

• Product Name: 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID
• Synonyms: AKOS B025025;AKOS BAR-0053;4'-FORMYL[1,1'-BIPHENYL]-3-CARBOXYLIC ACID;4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID;3-BIPHENYL-4'-FORMYL-CARBOXYLIC ACID;3-(4-FORMYLPHENYL)BENZOIC ACID;ART-CHEM-BB B025025;4μ-Formyl-[1,1μ-biphenyl]-3-carboxylic acid, 4μ-Formylbiphenyl-3-carboxylic acid
• CAS NO: 222180-20-3
• Molecular Formula: C14H10O3
• Molecular Weight: 226.23
• Product Categories: Heterocyclic Compounds
• Mol File: 222180-20-3.mol

Chemical Properties

• Melting Point: 188-192 °C(lit.)
• Boiling Point: 456.6°Cat760mmHg
• Flash Point: 244.1°C
• Appearance: /
• Density: 1.264g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID(222180-20-3)
• EPA Substance Registry System: 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID(222180-20-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 222180-20-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID is used as a reagent for the synthesis of sialosides, which are compounds that play a crucial role as CD22-specific inhibitors. These inhibitors are significant in the development of drugs targeting CD22, a protein involved in the regulation of the immune system. By modulating the activity of CD22, these inhibitors can potentially be used to treat autoimmune diseases and allergies.
In the synthesis process, 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID serves as a building block, providing the necessary structural elements for the formation of the desired sialosides. Its reactivity and functional groups facilitate the formation of the complex sialic acid linkages, which are essential for the biological activity of the resulting compounds.
Overall, 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID is a valuable chemical entity in the realm of pharmaceutical research and development, offering a promising avenue for the creation of novel therapeutic agents targeting CD22 and related pathways. Its unique structure and reactivity make it an essential component in the synthesis of bioactive molecules with potential applications in treating various diseases and conditions.

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 281234-49-9 methyl 4'-formylbiphenyl-3-carboxylate 
• 1219015-75-4 4-(3'-ethoxycarbonyl-biphenyl-4-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 1394050-81-7 ethyl 2-benzylidene-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-83-9 ethyl 2-(4-ethylbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-84-0 ethyl 2-(4-methylbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-86-2 ethyl 2-(4-methoxybenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-87-3 ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-88-4 ethyl 2-(4-chlorobenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-89-5 ethyl 2-(4-isopropylbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-90-8 ethyl 2-(4-tert-butylbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-91-9 ethyl 2-(4-nitrobenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 

Relevant articles and documents

Synthesis and biological activity of ethyl 2-(substituted benzylthio)-4-(3-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine- 5-carboxylate derivatives

In the present study, a new series of ethyl 2-(substituted benzylthio)-4-(3-(ethoxycarbonyl)-biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine- 5-carboxylate derivatives was synthesized. The newly synthesized compounds were characterized by 1H-NMR,

Synthesis and biological studies of novel biphenyl-3,5-dihydro-2H- thiazolopyrimidines derivatives

A new series of ethyl 2-(4-substitutedbenzylidene)-5-(3′- (ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a] pyrimidine-6-carboxylate derivatives (8a-j) were synthesized. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their In vitro antioxidant activity (Scavenging of hydrogen peroxide, Scavenging of nitric oxide radical, and Lipid peroxidation inhibitory activity), antibacterial (Escheria coli, Pseudonmonas aeruginosa (gram-negative bacteria), Bacillus sub-tillis, Staphylococcus aureus (gram-positive bacteria)) and antifungal (Candida albicans Aspergillus niger) studies.

Synthesis and anti-bacterial activity of new series of 4-(substituted biphenyl-4-yl)-6-methyl-2-oxo/thioxo-1,2,3, 4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

(Chemical Equation Presented) New series of 4-(substituted biphenyl-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester and 4-(substituted biphenyl-4-yl)-6-methyl-2-thioxo-1,2,3,4- tetrahydro-pyrimidine-5-carboxylic acid ethyl ester has been synthesized and the structures of the new compounds were established on the basis of 1H NMR, Mass (ES/MS), elemental analysis, and melting point. In-vitro antibacterial activity (MIC activity) was evaluated and compared with standard drugs ciprofloxacin, sparfloxacin, and trovafloxacin. Most of the compounds in this new series have shown moderate antibacterial activity against both Gram-positive and Gram-negative organisms.