22313-70-8

Basic information

• Product Name: Thiourea, N,N'-bis[(4-methoxyphenyl)methyl]-
• CAS NO: 22313-70-8
• Molecular Formula: C17H20N2O2S
• Molecular Weight: 316.424
• Mol File: 22313-70-8.mol

Chemical Properties

• CAS DataBase Reference: Thiourea, N,N'-bis[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N,N'-bis[(4-methoxyphenyl)methyl]-(22313-70-8)
• EPA Substance Registry System: Thiourea, N,N'-bis[(4-methoxyphenyl)methyl]-(22313-70-8)

Safety Data

• Hazardous Substances Data: 22313-70-8(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 2393-23-9 4-methoxy-benzylamine 
• 3694-57-3 1-(isothiocyanatomethyl)-4-methoxybenzene 
• 3717-21-3 (E)-4-methoxybenzaldoxime 

Downstream Products

• 57722-93-7 2,4-bis-(4-methoxy-benzyl)-3-thioxo-2,3,4,5-tetrahydro-benzo[e][1,3]diazepin-1-one 
• 1280723-00-3 3-(5-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid 
• 1280722-98-6 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid 
• 1280722-96-4 5-(4-hydroxybenzylidene)-3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)thiazolidin-4-one 

Relevant articles and documents

Rapid and highly efficient synthesis of thioureas in biocompatible basic choline hydroxide

A straightforward and convenient synthesis of symmetrical thiourea derivatives by the reaction of primary amines and carbon disulfide in biocompatible basic choline hydroxide is presented. A variety of biologically important thiourea derivatives can be obtained in good to excellent yields without a tedious work-up under mild reaction conditions. A series of primary aliphatic and aromatic amines with different substituted functional groups have been converted to thiourea derivatives under milder reaction conditions and short reaction times.

Convenient synthesis of 5-arylidene-2-imino-4-thiazolidinone derivatives using microwave irradiation

A concise approach for the preparation of 5-arylidene-2-imino-4- thiazolidinone derivatives is described. Structurally diverse amines, isothiocyanates, aldehydes, and chloroacetyl chloride were combined under microwave irradiation to afford new 5-arylidene-2-imino-4-thiazolidinone derivatives. The one-pot synthesis involves the in situ formation of a thiourea followed by reaction with chloroacetyl chloride and an aldehyde to generate the target compounds. Georg Thieme Verlag Stuttgart New York.

Thiazolidione derivatives as novel antibiofilm agents: Design, synthesis, biological evaluation, and structure-activity relationships

Rational designed novel thiazolidiones were synthesized and evaluated for antibiofilm activity. The active derivatives were not only potent inhibitors of Staphylococcus epidermidis biofilm growth but also efficient antibacterial agents. 3f showed 4-fold higher activity (6.25 μM) in the biofilms dispersal assay and significantly higher antibacterial activity (MIC 3.125 μM) in comparison to the 3-(5-((6- (ethoxycarbonyl)-5-(benzo[1,3]dioxol-5-yl)-3-oxo-7- phenyl- thiazolo[3,2-a]pyrimidin-2(5H)-ylidene)methyl)furan-2-yl)benzoic acid (1).

A concise synthesis of substituted thiourea derivatives in aqueous medium

(Figure Presented) An efficient method for the synthesis of symmetrical and unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such as amines and carbon disulfide in aqueous medium is presented. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives. The present method is also useful in synthesizing various substituted 2-mercapto imidazole heterocycles. This method proceeds through a xanthate (amino dithiol deivative) intermediate, unlike isothiocyanate as in an earlier known method.