2241598-34-3Relevant articles and documents
Sequential Pd0- and PdII-Catalyzed Cyclizations: Enantioselective Heck and Nucleopalladation Reactions
Arora, Ramon,Bajohr, Jonathan,Lautens, Mark,Torelli, Alexa,Whyte, Andrew
, p. 20231 - 20236 (2021/08/13)
An enantioselective consecutive cyclization/coupling process, catalyzed by palladium is reported. Stereoinduction arises from an enantioselective carbopalladation, generating an intermediate which promotes a nucleopalladation step. The dual cyclization se
Sulfonamide type chiral monophosphine ligand as well as preparation method and application thereof
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Paragraph 0045-0046; 0067-0068, (2018/12/14)
The invention discloses a sulfonamide type chiral monophosphine ligand. The chiral monophosphine ligand is a compound shown as a formula I in the description. The invention also discloses a syntheticmethod of the ligand. The method comprises the following
Palladium-Catalyzed Enantioselective Reductive Heck Reactions: Convenient Access to 3,3-Disubstituted 2,3-Dihydrobenzofuran
Zhang, Zhan-Ming,Xu, Bing,Qian, Yanyan,Wu, Lizuo,Wu, Yuanqi,Zhou, Lujia,Liu, Yu,Zhang, Junliang
supporting information, p. 10373 - 10377 (2018/07/31)
The first example of highly enantioselective intramolecular hydroarylation of allyl aryl ethers was realized by palladium-catalyzed reductive heck reactions utilizing a new chiral sulfinamide phosphine ligand (N-Me-XuPhos). N-Me-XuPhos can be easily prepared on gram scale from readily available starting materials in a one-pot synthesis approach. A series of optically active 2,3-dihydrobenzofurans bearing a quaternary stereocenter were obtained in good yields and with excellent enantioselectivities. The practicality of this reaction was validated in the straightforward synthesis of CB2 receptor agonists. Moreover, deuterium was efficiently incorporated into the products.