74684-38-1

Basic information

• Product Name: 2,4-DICHLOROPHENYLBUTYRIC ACID
• Synonyms: 2,4-DICHLOROPHENYLBUTYRIC ACID;3,5-Di-tert-butyl-4-methoxybenzaldehyde
• CAS NO: 74684-38-1
• Molecular Formula: C₁₆H₂₄O₂
• Molecular Weight: 233.09
• Mol File: 74684-38-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 352.011°C at 760 mmHg
• Flash Point: 166.69°C
• Appearance: /
• Density: 1.341g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-DICHLOROPHENYLBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROPHENYLBUTYRIC ACID(74684-38-1)
• EPA Substance Registry System: 2,4-DICHLOROPHENYLBUTYRIC ACID(74684-38-1)

Safety Data

• Hazardous Substances Data: 74684-38-1(Hazardous Substances Data)

Usage

General Description

2,4-Dichlorophenylbutyric acid, also known as 2,4-DB, is a synthetic herbicide that is commonly used to control broadleaf weeds in a variety of crops and grasslands. It works by mimicking the natural plant hormone auxin, which disrupts the normal growth and development of the targeted weeds. 2,4-DB is primarily absorbed through the leaves of plants, and acts by causing uncontrolled growth, leading to the eventual death of the weed. It is considered moderately toxic to humans and animals, and can cause skin and eye irritation if not handled properly. Proper usage and application is important to prevent harmful effects on non-target organisms and the environment.

InChI:InChI=1/C10H10Cl2O2/c11-8-5-4-7(9(12)6-8)2-1-3-10(13)14/h4-6H,1-3H2,(H,13,14)

Upstream product

• 1516-96-7 4-bromo-2,6-di-tert-butylanisole 
• 68-12-2 N,N-dimethyl-formamide 
• 1516-95-6 2,6-di-tert-butyl-anisole 
• 110-54-3 hexane 
• 74-88-4 methyl iodide 
• 1620-98-0 3,5-di-t-butyl-4-hydroxybenzaldehyde 
• 1262766-27-7 C₁₆H₂₄Br₂O 
• 74222-81-4 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 88-26-6 3,5-di-tert-butyl-4-hydroxybenzyl alcohol 

Downstream Products

• 113894-13-6 1,3-di-tert-butyl-5-[(E)-2-(3,5-di-tert-butyl-4-methoxyphenyl)ethenyl]-2-methoxybenzene 
• 93629-15-3 5-(bromomethyl)-1,3-di-tert-butyl-2-methoxybenzene 
• 1016636-85-3 diethyl (3,5-di-tert-butyl-4-methoxybenzyl)phosphonate 
• 1261146-15-9 (1E,3E)-1,4-bis(3,5-di-tert-butyl-4-methoxyphenyl)buta-1,3-diene 

Relevant articles and documents

ALPHAvBETA1 INTEGRIN ANTAGONISTS

The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβ1 and/or α5β1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.

Photosensitive porphyrin dyes for dye-sensitized solar cells

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New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription

We have synthesized a series of new (E) stilbenoid derivatives containing hydroxy groups at ring positions identical or similar to those of trans-resveratrol and bearing one or two bulky electron donating groups ortho to 4′-OH and we have evaluated their neuroprotective activity using glutamate-challenged HT22 hippocampal neurons to model oxidative stress-induced neuronal cell death. The most active derivatives, 5-{(E)-2-[3,5-bis(1- ethylpropyl)-4-hydroxyphenyl]ethenyl}-1,3-benzenediol (2), 5-[(E)-2-(3,5-di- tert-butyl-4-hydroxyphenylethenyl)]-1,3-benzenediol (4) and 5-{(1E,3E)-4-[3,5- bis(1-ethylpropyl)-4-hydroxyphenyl]-1,3-butadienyl}-1,3-benzenediol (6), had EC50 values of 30, 45 and 12 nM, respectively, and were ca. 100 to 400-fold more potent than resveratrol. Derivatives 2, 4 and 6 lacked cytotoxic activity against HT22 cells and estrogen receptor agonist or antagonist activity in estrogen response element-dependent gene expression and in estrogen-dependent proliferation of MCF-7 human breast cancer cells. In addition, they were incapable of interfering with aryl hydrocarbon receptor-mediated xenobiotic response element-dependent gene expression. Derivatives 2, 4 and 6 might assist in the development of lead candidates against oxidative stress-driven neurodegenerative diseases that will not increase endocrine cancer risk nor affect drug activation and detoxification mechanisms.