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226889-35-6

D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-

    Cas No: 226889-35-6

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  • 226889-35-6 Structure

  • Basic information

    1. Product Name: D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-
    2. Synonyms: D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-
    3. CAS NO:226889-35-6
    4. Molecular Formula: C37H44 O6
    5. Molecular Weight: 584.75
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 226889-35-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-(CAS DataBase Reference)
    10. NIST Chemistry Reference: D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-(226889-35-6)
    11. EPA Substance Registry System: D-myo-Inositol, 2,4,5-tris-O-(phenylmethyl)-1,6-O-(1R,2S,4R)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-(226889-35-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 226889-35-6(Hazardous Substances Data)

226889-35-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 226889-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,8,8 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 226889-35:
(8*2)+(7*2)+(6*6)+(5*8)+(4*8)+(3*9)+(2*3)+(1*5)=176
176 % 10 = 6
So 226889-35-6 is a valid CAS Registry Number.

226889-35-6Relevant articles and documents

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

Conway, Stuart J.,Gardiner, James,Grove, Simon J. A.,Johns, Melloney K.,Lim, Ze-Yi,Painter, Gavin F.,Robinson, Diane E. J. E.,Schieber, Christine,Thuring, Jan W.,Wong, Leon S.-M.,Yin, Meng-Xin,Burgess, Antony W.,Catimel, Bruno,Hawkins, Phillip T.,Ktistakis, Nicholas T.,Stephens, Leonard R.,Holmes, Andrew B.

scheme or table, p. 66 - 76 (2010/04/29)

The synthesis of the complete family of phosphatidylinositol phosphate analogues (PIPs) from five key core intermediates A-E is described. These core compounds were obtained from myo-inositol orthoformate 1 via regioselective DIBAL-H and trimethylaluminium-mediated cleavages and a resolution-protection process using camphor acetals 10. Coupling of cores A-E with phosphoramidites 34 and 38, derived from the requisite protected lipid side chains, afforded the fully-protected PIPs. Removal of the remaining protecting groups was achieved via hydrogenolysis using palladium black or palladium hydroxide on carbon in the presence of sodium bicarbonate to afford the complete family of dipalmitoyl- and amino-PIP analogues 42, 45, 50, 51, 58, 59, 67, 68, 76, 77, 82, 83, 92, 93, 99 and 100. Investigations using affinity probes incorporating these compounds have identified novel proteins involved in the PI3K intracellular signalling network and have allowed a comprehensive proteomic analysis of phosphoinositide interacting proteins. The Royal Society of Chemistry 2010.

General synthesis of 3-phosphorylated mj'o-inositol phospholipids and derivatives

Painter, Gavin F.,Grove, Simon J. A.,Gilbert, Lan H.,Holmes, Andrew B.,Raithby, Paul R.,Hill, Malcolm L.,Hawking, Phillip T.,Stephens, Leonard R.

, p. 923 - 935 (2007/10/03)

The D-3-phosphorylated wyo-inositol phospholipids PtdIns(3)P, PtdIns(3,4)P2, PtdIns(3,4,5)P3 and PtdIns(3,5)P2 were synthesised from /yo-inositol orthoformate 8. Key transformations included the regioselective DIBAL- and trimethylaluminium-mediated cleavages of wiyo-inositol orthoformate intermediates and a resolution-protection protocol using the camphor acetals 17. The final reductive debenzylation was effected with Pearlman's catalyst [Pd(OH)J in the presence of sodium hydrogen carbonate. The biological properties of the phospholipids were evaluated against various protein kinases (PKB and PDK-1) in which they played an important activation role.

Versatile synthesis of myo-inositol phospholipid precursors

Grove, Simon J. A.,Gilbert, Ian H.,Holmes, Andrew B.,Painter, Gavin F.,Hill, Malcolm L.

, p. 1633 - 1634 (2007/10/03)

Homochiral myo-inositol derivatives 16 and 20 and their corresponding enantiomers possessing either the natural or unnatural ring stereochemistry for inositol phospholipids are synthesised from myo-inositol derivatives 8 and 9 respectively using camphor d

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