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2-(Dimethylamino)-6-methyl-4-pyridinecarboxylic acid, also known as DMAP, is a versatile chemical compound that serves as a catalyst in organic synthesis. It is a strong nucleophilic base, particularly effective in promoting esterification and acylation reactions. DMAP is a white crystalline solid with a characteristic amine odor and is soluble in organic solvents such as dichloromethane and dimethylformamide.

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  • 226917-15-3 Structure
  • Basic information

    1. Product Name: 2-(Dimethylamino)-6-methyl-4-pyridinecarboxylicacid
    2. Synonyms: 2-(dimethylamino)-6-methylpyridine-4-carboxylic acid;2-Dimethylamino-6-methylisonicotinic acid
    3. CAS NO:226917-15-3
    4. Molecular Formula: C9H12N2O2
    5. Molecular Weight: 180.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 226917-15-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 420.4°C at 760 mmHg
    3. Flash Point: 208.1°C
    4. Appearance: /
    5. Density: 1.205g/cm3
    6. Vapor Pressure: 8.07E-08mmHg at 25°C
    7. Refractive Index: 1.589
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(Dimethylamino)-6-methyl-4-pyridinecarboxylicacid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(Dimethylamino)-6-methyl-4-pyridinecarboxylicacid(226917-15-3)
    12. EPA Substance Registry System: 2-(Dimethylamino)-6-methyl-4-pyridinecarboxylicacid(226917-15-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 226917-15-3(Hazardous Substances Data)

226917-15-3 Usage

Uses

Used in Pharmaceutical and Fine Chemical Industries:
2-(Dimethylamino)-6-methyl-4-pyridinecarboxylic acid is used as a catalyst for the synthesis of various compounds, including pharmaceutical intermediates and natural products. Its strong nucleophilic base properties make it particularly effective in promoting esterification and acylation reactions, which are crucial in the production of these compounds.
Used in Polymer and Dye Production:
2-(Dimethylamino)-6-methyl-4-pyridinecarboxylic acid is used as a catalyst in the production of polymers and dyes. Its ability to promote esterification and acylation reactions contributes to the synthesis of these materials, enhancing their properties and performance.
Used in the Development of New Materials and Chemical Processes:
2-(Dimethylamino)-6-methyl-4-pyridinecarboxylic acid is used as a catalyst in the development of new materials and chemical processes. Its versatility and effectiveness in promoting esterification and acylation reactions make it an important chemical in the field of organic chemistry, enabling the creation of innovative materials and processes.

Check Digit Verification of cas no

The CAS Registry Mumber 226917-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,9,1 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 226917-15:
(8*2)+(7*2)+(6*6)+(5*9)+(4*1)+(3*7)+(2*1)+(1*5)=143
143 % 10 = 3
So 226917-15-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O2/c1-6-4-7(9(12)13)5-8(10-6)11(2)3/h4-5H,1-3H3,(H,12,13)

226917-15-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(dimethylamino)-6-methylpyridine-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 2-dimethylamino-6-methyl-isonicotinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:226917-15-3 SDS

226917-15-3Relevant articles and documents

NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES

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, (2011/04/14)

The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS

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, (2011/09/20)

The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.

AMINO-PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS

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Page/Page column 12, (2010/04/30)

The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES

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, (2009/10/22)

The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula I.

PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS

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Page/Page column 50-51, (2009/04/25)

The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituants are as defined in the claims.

AMINO- PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS

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, (2008/12/07)

The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

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