2-(Dimethylamino)-6-methylpyridine-4-carboxylic acid

Base Information

• Chemical Name: 2-(Dimethylamino)-6-methylpyridine-4-carboxylic acid
• CAS No.: 226917-15-3
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.2
• DSSTox Substance ID: DTXSID20591607
• Wikidata: Q82485409
• Mol file: 226917-15-3.mol

Synonyms:226917-15-3;2-(dimethylamino)-6-methylpyridine-4-carboxylic acid;2-dimethylamino-6-methyl-isonicotinic acid;2-dimethylamino-6-methylisonicotinic acid;SCHEMBL1179043;DTXSID20591607;XNICZRGXAXLQTF-UHFFFAOYSA-N;DB-330302;2-(DIMETHYLAMINO)-6-METHYL-4-PYRIDINECARBOXYLICACID

Chemical Property of 2-(Dimethylamino)-6-methylpyridine-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 8.07E-08mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 420.4°C at 760 mmHg
• Flash Point: 208.1°C
• PSA: 53.43000
• Density: 1.205g/cm³
• LogP: 1.15420
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 194

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)N(C)C)C(=O)O

Technology Process of 2-(Dimethylamino)-6-methylpyridine-4-carboxylic acid

There total 6 articles about 2-(Dimethylamino)-6-methylpyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-methyl-isonicotinic acid tert.-butyl ester (849226-45-5) + dimethyl amine (124-40-3) → 2-dimethylamino-6-methyl-isonicotinic acid (226917-15-3)

Guidance literature:

2-chloro-6-methyl-isonicotinic acid tert.-butyl ester; dimethyl amine; With sodium t-butanolate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 110 ℃; for 18h;

With hydrogenchloride; water; at 100 ℃; for 18h;

With sodium hydroxide; In water;

Reference yield:

2-chloro-6-methylisonicotinic acid ethyl ester (3998-88-7) + dimethyl amine (124-40-3) → 2-dimethylamino-6-methyl-isonicotinic acid (226917-15-3)

Guidance literature:

2-chloro-6-methylisonicotinic acid ethyl ester; dimethyl amine; With sodium t-butanolate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 110 ℃; for 42h; Inert atmosphere;

With hydrogenchloride; In water; at 100 ℃; for 18h;

With sodium hydroxide; In water;

Reference yield:

C11H16N2O2 → 2-dimethylamino-6-methyl-isonicotinic acid (226917-15-3)

Guidance literature:

C₁₁H₁₆N₂O₂; With hydrogenchloride; water; at 100 ℃; for 18h;

With sodium hydroxide; In water;

upstream raw materials:

2-chloro-6-methyl-isonicotinic acid tert.-butyl ester

dimethyl amine

C₁₃H₂₀N₂O₂

2-chloro-6-methylisonicotinic acid ethyl ester

Downstream raw materials:

C₂₂H₂₈N₄O₃

C₂₂H₂₈N₄O₃

rac-3-{4-[5-(2-dimethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

{4-[3-(4-allyloxy-3-ethyl-5-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-6-methyl-pyridin-2-yl}-dimethyl-amine