- Analgesic and myotonolytic preparations
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Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.
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- Process for preparing 2(1H)-quinazolinone derivatives
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2(1H)-Quinazolinone and quinazolinethione derivatives having excellent pharmacological activities are produced in high yield with high purity by heating the corresponding 3,4-dihydro-2(1H)-quinazolinone or quinazolinethione derivatives together with sulfur in an inert solvent.
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- Tetrahydro-2(1H)-quinazolinones and cyclohexene nitriles
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A process for the production of 4-phenyl-2(1H)-quinazolinones and -4a,5,6,8a-tetrahydro-2(1H)-quinazolinones which comprises introducing the desired phenyl radical into a corresponding quinazolin-2,4(1H,3H)-dione by way of a Grignard reaction and hydrolysis of the resulting product.
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- Preparation of quinazolin-2(1H)-ones
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The invention provides a process for the production of 4-phenyl-2(1H)-quinazolinones by cyclising a corresponding 2-aminobenzophenone with urea or an alkylcarbamate in the presence of an aromatic acid. The products are known anti-inflammatory agents.
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- Preparation of quinazolin-2(1H)-ones
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Quinazoline-2(1H)-ones are prepared by dehydrogenating a 5,6,7,8-tetrahydro-2(1H)-quinazolinone with sulfur in the presence of a metal oxide, hydroxide or halide.
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- Process for preparing quinazolines
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Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.
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- 7-Methyl-1-isopropyl-4-phenyl-5,6,7,8-tetrahydro-2(1H)-quinazolinone
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Compounds of the formula I: SPC1 wherein R° is lower alkyl, n is 0, 1 or 2, R is lower alkyl, R' is a radical of the formula SPC2 In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula SPC3 In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, Are prepared by cyclizing a compound of formula II SPC4 in which R, R', R° and n are as defined above, with phosgene, or, Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C1 -C2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.
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