22760-18-5

Usage

Uses

Used in Pharmaceutical Industry:
Proquazone is used as an anti-inflammatory agent for reducing pain and inflammation associated with various conditions such as arthritis, tendonitis, and other musculoskeletal disorders. Its non-steroidal nature allows for a safer and more effective treatment option compared to traditional steroidal anti-inflammatory drugs.
Used in Pain Management:
Proquazone is also used in pain management for conditions that involve mild to moderate pain, such as headaches, menstrual cramps, and dental pain. Its ability to reduce inflammation and alleviate pain makes it a popular choice for patients seeking relief from these types of discomfort.

InChI:InChI=1/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 40235-08-3 1-isopropyl-7-methyl-4-phenyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one 
• 598-55-0 methyl carbamate 
• 23070-81-7 2-(N-isopropylamino)-4-methylbenzophenone 

Relevant academic research and scientific papers

Analgesic and myotonolytic preparations

Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.

Tetrahydro-2(1H)-quinazolinones and cyclohexene nitriles

A process for the production of 4-phenyl-2(1H)-quinazolinones and -4a,5,6,8a-tetrahydro-2(1H)-quinazolinones which comprises introducing the desired phenyl radical into a corresponding quinazolin-2,4(1H,3H)-dione by way of a Grignard reaction and hydrolysis of the resulting product.

Process for preparing 2(1H)-quinazolinone derivatives

2(1H)-Quinazolinone and quinazolinethione derivatives having excellent pharmacological activities are produced in high yield with high purity by heating the corresponding 3,4-dihydro-2(1H)-quinazolinone or quinazolinethione derivatives together with sulfur in an inert solvent.

Preparation of quinazolin-2(1H)-ones

The invention provides a process for the production of 4-phenyl-2(1H)-quinazolinones by cyclising a corresponding 2-aminobenzophenone with urea or an alkylcarbamate in the presence of an aromatic acid. The products are known anti-inflammatory agents.

Preparation of quinazolin-2(1H)-ones

Quinazoline-2(1H)-ones are prepared by dehydrogenating a 5,6,7,8-tetrahydro-2(1H)-quinazolinone with sulfur in the presence of a metal oxide, hydroxide or halide.

7-Methyl-1-isopropyl-4-phenyl-5,6,7,8-tetrahydro-2(1H)-quinazolinone

Compounds of the formula I: SPC1 wherein R° is lower alkyl, n is 0, 1 or 2, R is lower alkyl, R' is a radical of the formula SPC2 In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula SPC3 In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, Are prepared by cyclizing a compound of formula II SPC4 in which R, R', R° and n are as defined above, with phosgene, or, Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C1 -C2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.

Process for preparing quinazolines

Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.