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Basic Information
CAS No.: 22760-18-5
Name: proquazone
Molecular Structure:
Molecular Structure of 22760-18-5 (proquazone)
Formula: C18H18 N2 O
Molecular Weight: 278.354
Synonyms: 2(1H)-Quinazolinone,1-isopropyl-7-methyl-4-phenyl- (8CI);1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone;1-Isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one; Anthrex; Biarison;Proquazone; RU 43-715; SAN 43-715; SaH 43-715; Sandoz 43-715
Density: 1.12g/cm3
Melting Point: 137-138°
Boiling Point: 440.6°Cat760mmHg
Flash Point: 220.3°C
Safety: Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
PSA: 34.89000
LogP: 3.95280
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Chemistry

Product Name: Proquazone (CAS NO.22760-18-5 )


Molecular Formula: C18H18N2O
Molecular Weight: 278.3483g/mol
Mol File: 22760-18-5 .mol
Einecs: 245-203-7
Boiling point: 440.6 °C at 760 mmHg
Flash Point: 220.3 °C
Density: 1.12 g/cm3
Surface Tension: 40.1 dyne/cm
Enthalpy of Vaporization: 69.78 kJ/mol
Vapour Pressure: 5.79E-08 mmHg at 25°C
XLogP3-AA: 3
H-Bond Donor: 0
H-Bond Acceptor: 1
Structure Descriptors of Proquazone (CAS NO.22760-18-5 ):
  IUPAC Name: 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
  Canonical SMILES: CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
  InChI: InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 
  InChIKey: JTIGKVIOEQASGT-UHFFFAOYSA-N

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 800mg/kg (800mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
mouse LD50 intraperitoneal 339mg/kg (339mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 879, 1984.
mouse LD50 oral 930mg/kg (930mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rabbit LD50 oral 260mg/kg (260mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ANTIPSYCHOTIC		 Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rat LD50 intraperitoneal 375mg/kg (375mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ANTIPSYCHOTIC		 Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rat LD50 oral 759mg/kg (759mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

Specification

 Proquazone ,its CAS NO. is 22760-18-5 ,the synonyms is 1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone ; 5-24-04-00375 (Beilstein Handbook Reference) ; Arthrex ; BRN 0889725 ; Biarison ; EINECS 245-203-7 ; Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone ; RU 43715 ; SaH 43-715 ; Sandoz 43-715 ; UNII-42VPJ2980S ; 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl- ; 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl- .