228710-83-6

Basic information

• Product Name: 2-chloro-1-(6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl)ethanone
• Synonyms: 2-chloro-1-(6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl)ethanone
• CAS NO: 228710-83-6
• Molecular Formula: C₁₃H₁₃ClN₂O
• Molecular Weight: 248.70812
• Mol File: 228710-83-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-1-(6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl)ethanone(228710-83-6)
• EPA Substance Registry System: 2-chloro-1-(6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl)ethanone(228710-83-6)

Safety Data

• Hazardous Substances Data: 228710-83-6(Hazardous Substances Data)

Upstream product

• 228710-82-5 5-bromo-2-(2,5-dimethyl-pyrrol-1-yl)-pyridine 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 110-13-4 2,5-hexanedione 

Relevant articles and documents

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This invention relates to a novel salt form of dopamine agonist 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine (I): More particularly, this invention relates to 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine di-(1 S)-camphorsulfonate (di-S-camsylate) and to processes for the preparation of, intermediates used in the preparation of, compositions containing, and the uses of this salt.

Novel salt form of a dopamine agonist

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The present invention provides for compounds of formula (I) which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

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Previously our group reported synthetic efforts used to synthesize kilogram quantities of the β-3 receptor agonist (R)-(4-(2-(2-(6-aminopyridin-3-yl)- 2-hydroxyethylamino)ethoxy)phenyl)-acetic acid, 1. Additional research was conducted to explore an alternate chiral route with a streamlined protecting group scheme. The alternate asymmetric process and synthetic rationale are described.

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The present invention provides for compounds of formula (I), (la) and (lb) Wherein: A is selected from C-X and N, B is selected from C-Y and N, R1 is selected from H and (C1-C6)alkyl R2 is selected from H and (C

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