228710-82-5

Usage

Uses

Used in Organic Synthesis:
5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine is used as a reactant and reagent for the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, such as cross-coupling, substitution, and condensation reactions, enabling the formation of diverse molecular architectures with potential applications in different fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine is used as a key intermediate in the development of new drugs. Its ability to form a variety of organic compounds makes it a valuable tool for medicinal chemists, who can use it to create novel drug candidates with potential therapeutic properties.
Used in Chemical Research:
5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine is also utilized in academic and industrial research settings, where it serves as a starting material for exploring new reaction pathways and developing innovative synthetic methods. Its reactivity and structural diversity make it an attractive candidate for studying various aspects of organic chemistry, including reaction mechanisms, stereochemistry, and catalyst design.
Used in Material Science:
In the field of material science, 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine can be employed as a building block for designing new materials with specific properties, such as optoelectronic materials, sensors, or advanced polymers. Its unique structure and reactivity allow for the creation of materials with tailored characteristics, which can be applied in various technological applications.

InChI:InChI=1/C11H11BrN2/c1-8-3-4-9(2)14(8)11-6-5-10(12)7-13-11/h3-7H,1-2H3

Upstream product

• 110-13-4 2,5-hexanedione 
• 1072-97-5 5-bromo-2-pyridylamine 
• 7440-44-0 pyrographite 

Downstream Products

• 228710-83-6 2-chloro-1-[6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-3-yl]-ethanone 
• 10167-97-2 2-amino-5-methoxypyridine 
• 55717-46-9 6-aminopyridin-3-ol 
• 638352-78-0 1-(5-methoxypyridin-2-yl)-2,5-dimethyl-1H-pyrrole 
• 1198408-35-3 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester 
• 1249400-92-7 5-(2-(dimethylamino)ethoxy)pyridin-2-amine 

Relevant academic research and scientific papers

Alternate synthesis of a β-3 adrenergic receptor agonist

Previously our group reported synthetic efforts used to synthesize kilogram quantities of the β-3 receptor agonist (R)-(4-(2-(2-(6-aminopyridin-3-yl)- 2-hydroxyethylamino)ethoxy)phenyl)-acetic acid, 1. Additional research was conducted to explore an alternate chiral route with a streamlined protecting group scheme. The alternate asymmetric process and synthetic rationale are described.

Synthesis of 2-amino-5-hydroxypyridine via demethoxylation

A convenient and efficient four-step synthesis of 2-amino-5-hydroxypyridine can be achieved by protective reaction of 2-amino-5-bromopyridine in the presence of 2,5-hexanedione to yield 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1yl)pyridine, methoxylation with sodium methylate to give 5-methoxy-2-(2,5-dimethyl-1H-pyrrol-1yl)pyridine, deprotective reaction with hydroxylamine hydrochloride to produce 2-amino-5-methoxypyridine and demethylation with 95 % H2SO4 to afford the title compound in an overall yield of 45 %.

PROLYL HYDROXYLASE INHIBITORS

The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I), which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN

The present invention relates to use of a compound of formula (I), (Ia), or (Ib), wherein A, B, Z, R1and R2 have the meanings given in the specification, as a medicament for the treatment of a number of pain conditions, particularly chronic or nociceptive

NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS

This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

BENZAZEPIN-2(1H)-ONE DERIVATIVES

Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.

TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS

The present invention provides a compound of the formula: Formula I or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or ex

NOVEL SALT FORM OF A DOPAMINE AGONIST

This invention relates to a novel salt form of dopamine agonist 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine (I): More particularly, this invention relates to 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine di-(1 S)-camphorsulfonate (di-S-camsylate) and to processes for the preparation of, intermediates used in the preparation of, compositions containing, and the uses of this salt.

Novel salt form of a dopamine agonist

This invention relates to a novel salt form of dopamine agonist 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine (I): More particularly, this invention relates to 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine di-(1S)-camphorsulfonate (di-S-camsylate) and to processes for the preparation of, intermediates used in the preparation of, compositions containing, and the uses of this salt.

ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE

Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula (I). A representative example is formula (II