22921-72-8Relevant articles and documents
Self-assembly studies of allosteric photosynthetic antenna model systems
Thomassen, Paul J.,Foekema, Jantien,I Lluch, Ribera Jordana,Thordarson, Pall,Elemans, Johannes A. A. W.,Nolte, Roeland J. M.,Rowan, Alan E.
, p. 148 - 155 (2006)
In this paper allosteric interactions are employed to enhance electron transfer in a pseudorotaxane system. Binding of an axial ligand (tbpy) to an electron donating mono-cavity appended zinc porphyrin (ZnP) increases the complexation strength to an elect
Regiodivergent Conversion of Alkenes to Branched or Linear Alkylpyridines
Kim, Minseok,Shin, Sanghoon,Koo, Yejin,Jung, Sungwoo,Hong, Sungwoo
supporting information, p. 708 - 713 (2022/01/20)
Herein we report a practical protocol for the visible-light-induced regiodivergent radical hydropyridylation of unactivated alkenes using pyridinium salts. This approach provides a unified synthetic platform to control the regioselectivity of the synthesis of linear or branched C4-alkylated pyridines. A remarkable selectivity switch from the anti-Markovnikov to the Markovnikov product can be achieved by the addition of tetrabutylammonium bromide. The versatility of this protocol is further demonstrated based on the late-stage functionalization in pharmaceuticals.
2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS
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Page/Page column 51; 52, (2017/02/09)
The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.
Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent
Yin, Wei,Lan, Li,Huang, Zhangjian,Ji, Jing,Fang, Jiangen,Wang, Xiaoli,Ji, Hui,Peng, Sixun,Xu, Jinyi,Zhang, Yihua
, p. 369 - 380 (2016/04/06)
To search for novel anti-ischemic stroke agents with higher potency than a known drug 3-n-butylphthalide (NBP), a series of ring-opened derivatives of NBP bearing both nitric oxide (NO) and hydrogen sulfide (H2S)-donating moieties (NO/H2S-NBP) (8a-8o) were designed, synthesized, and biologically evaluated. The most active compound 8d was more potent than NBP and the corresponding H2S-NBP 10 or NO-NBP 13 in inhibition of the ADP-induced platelet aggregation in vitro. In addition, 8d produced moderate levels of NO and H2S, which could be beneficial for improving cardiovascular and cerebral circulation. More importantly, in a rat model of transient focal cerebral ischemia, oral treatment with 8d improved neurobehavioral function, reduced the infarct brain size and brain-water content, and enhanced the levels of brain antioxidant SOD, GSH and GSH-Px but diminished the level of oxidant MDA. These protective effects of 8d against the ischemia/reperfusion (I/R)-related brain damage were greater than that of NBP, suggesting that 8d may be a promising agent for further investigation.
ω-Phenoxyalkyl substituted bis(indenyl)zirconium dichloride complexes as catalysts for homogeneous ethylene polymerization
Ahmad, Khalil,Alt, Helmut G.
, p. 63 - 71 (2015/06/02)
Nine bis(indenyl)zirconium dichloride complexes of the type [C9H6-(CH2)n-O-Ar]2ZrCl2 (n = 3-5; Ar = Ph, t-Bu-Ph) were synthesized, characterized, activated with methylalumoxane (MAO) and tested for ethylene polymerization. Structure-property-relationship studies showed that the activities of the catalysts depend on the length of the bridging chain between the indenyl and the phenoxy group as well as on the bulk at the phenoxy substituent. A t-Bu substituent at the ortho position of the phenoxy group (5a/MAO) gives a much higher catalyst activity (27,500 kg PE/mol cat h) than the isomer 8a/MAO with a t-Bu substituent at the para position of the phenoxy group (16,700 kg PE/mol cat h). Obviously substituents in the ortho position of the phenyl ring generate a bulkier catalyst cation and this can keep the MAO anion at a further distance to allow easier ethylene coordination and chain growth in the polymerization steps. The mono substituted bis(indenyl) complex (C9H7)[C9H6-(CH2)4-O-4-t-Bu]ZrCl2 shows lower activity (11,700 kg PE/mol cat h) than 8a indicating that the electronic effect is dominating in this type of catalysts.
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Babkov, Denis A.,Khandazhinskaya, Anastasia L.,Chizhov, Alexander O.,Andrei, Graciela,Snoeck, Robert,Seley-Radtke, Katherine L.,Novikov, Mikhail S.
, p. 7035 - 7044 (2015/11/11)
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
1-Phenoxyalkyl-4-[(N,N-disubstitutedamino)alkyl]piperazine derivatives as non-imidazole histamine H3-antagonists
Staszewski, Marek,Walczynski, Krzysztof
, p. 1287 - 1304 (2013/04/10)
In this study, a series of 1-phenoxyalkyl-4-[(N,N-disubstitutedamino)alkyl] piperazine derivatives has been prepared and in vitro tested as H 3-receptor antagonists (electrically evoked contraction of the guinea pig jejunum). All compounds inve
Fast synthesis employing a microwave assisted neat protocol of new monomers potentially useful for the preparation of PDLC films
Barros, M. Teresa,Mouquinho, Ana I.,Petrova, Krasimira T.,Saavedra, Mara D.,Sotomayor, Joao C.
experimental part, p. 557 - 566 (2012/04/10)
It has been repor ted that the length of the molecular chain and the rigidity of molecules influence the structure of the polymer network in PDLC films and hence the electro-optical proper ties of the composites. Herein, a series of new aromatic monomeric monomethacrylates, bismethacrylates and monovinylbenzene derivatives with a mesogenic core were successfully synthesized under microwave irradiation. The microwave assisted synthesis resulted in decreased reaction times, reduced solvent requirement, increased operational simplicity, and in most cases, improved yields and selectivity. Versita Sp. z o.o.
Synthesis and studies of Rh(I) catalysts within and across poly(alkyl aryl ether) dendrimers
Natarajan, Baskar,Jayaraman, Narayanaswamy
supporting information; experimental part, p. 722 - 730 (2011/03/18)
In order to study the efficiencies of catalytic moieties within and across dendrimer generations, partially and fully functionalized dendrimers were synthesized. Poly(alkyl aryl ether) dendrimers from zero to three generations, presenting 3 to 24 peripher
Films based on new methacrylate monomers: Synthesis, characterisation and electro-optical properties
Mouquinho, Ana,Saavedra, Mara,Maiau, Alexandre,Petrova, Krasimira,Barros, M. Teresa,Figueirinhas,Sotomayor, Joao
scheme or table, p. 132 - 140 (2012/01/06)
A number of liquid crystal monomers based on methacrylate derivatives were synthesised by novel mild and solventless procedures under microwave irradiation. Their photo- and thermo assisted homo- and co-polymerizations with glycidyl methacrylate were investigated. The resulting polymers were characterised by NMR, GPC, DSC, and SEM to determine their structures and properties. The effects of the structures of the monomers on the electro-optical properties were correlated. Copyright Taylor & Francis Group, LLC.