7170-40-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Phenoxy-N-valeric acid is used as an antihypertensive agent for the treatment of high blood pressure. It helps in relaxing blood vessels, which in turn lowers blood pressure and reduces the risk of cardiovascular complications.
5-Phenoxy-N-valeric acid is also used as a therapeutic agent for heart failure. It improves the symptoms of heart failure by reducing the workload on the heart and promoting better blood circulation.
Furthermore, valsartan is used to decrease the risk of death in individuals who have experienced a heart attack. By managing blood pressure and improving heart function, it contributes to better overall cardiovascular health and reduces the likelihood of further cardiac events.

Upstream product

• 74972-56-8 (hex-5-en-1-yloxy)benzene 
• 69687-95-2 ethyl 5-(phenoxy)pentanoate 
• 854879-95-1 2-(3-phenoxy-propyl)-acetoacetic acid ethyl ester 
• 63258-09-3 (3-phenoxy-propyl)-malonic acid 
• 124-38-9 carbon dioxide 
• 1200-03-9 4-bromophenyl butyl ether 
• 5454-83-1 5-bromovaleric acid methyl ester 
• 108-95-2 phenol 
• 139-02-6 sodium phenoxide 
• 6345-89-7 (3-phenoxypropyl)diethyl propanedioate 
• 588-63-6 3-phenoxypropyl bromide 
• 3384-04-1 3-chloropropyl phenyl ether 
• 1927-71-5 4-phenoxybutan-1-ol 
• 2653-89-6 4-phenoxy-1-butene 

Downstream Products

• 69687-95-2 ethyl 5-(phenoxy)pentanoate 
• 2067-33-6 5-bromopentanoic acid 
• 214417-36-4 5-phenoxy-valeryl chloride 
• 16654-52-7 5-phenoxy-1-pentanol 
• 61797-44-2 5-Phenoxy-pentanoic acid methyl-{2-[methyl-(5-phenoxy-pentanoyl)-amino]-ethyl}-amide 
• 108-95-2 phenol 
• 75736-50-4 1-Brom-<5,5,5-D3>pentan 
• 55320-69-9 6,6,6-trideuteriohexanoic acid 
• 84615-44-1 1-Phenoxy-<5,5,5-D3>pentan 
• 84615-43-0 p-Toluolsulfonsaeure-(5-phenoxy-<1,1-D2>pentylester) 
• 51795-98-3 1-bromo-7-phenoxyheptane 
• 22921-72-8 (5-bromopentoxy)benzene 
• 7170-42-5 7-phenoxy-heptanoic acid 
• 92865-48-0 (5-phenoxy-pentyl)-malonic acid 

Relevant academic research and scientific papers

2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS

The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

Cp2TiCl2-Catalyzed Regioselective Hydrocarboxylation of Alkenes with CO2

Cp2TiCl2-catalyzed regioselective hydrocarboxylation of alkenes with CO2 to give carboxylic acids in high yields has been developed in the presence of iPrMgCl. The reaction proceeds with a wide range of alkenes under mild conditions. Styrene and its derivatives can transform to α-aryl carboxylic acids, and aliphatic alkenes can transform to form alkanoic acids.

FATTY ACID AMIDE HYDROLASE INHIBITORS

Disclosed are compounds of formula R-X-Y that may be used to inhibit the action of fatty acid amide hydrolase (FAAH). Inhibition of fatty acid amide hydrolase (FAAH) will slow the normal degradation and inactivation of endogenous cannabinoid ligands by FAAH hydrolysis and allow higher levels of those endogenous cannabinergic ligands to remain present. These higher levels of endocannabinoid ligands provide increased stimulation of the cannabinoid CBl and CB2 receptors and produce physiological effects related to the activation of the cannabinoid receptors. They will also enhance the effects of other exogenous cannabinergic ligands and allow them to produce their effects at lower concentrations as compared to systems in which fatty acid amide hydrolase (FAAH) action is hot inhibited. Thus, a compound that inhibits the inactivation of endogenous cannabinoid ligands by fatty acid amide hydrolase (FAAH) may increase the levels of endocannabinoids and, thus, enhance the activation of cannabinoid receptors. Thus, the compound may not directly modulate the cannabinoid receptors but has the effect of indirectly stimulating the cannabinoid receptors by increasing the levels of endocannabinoid ligands. It may also enhance the effects and duration of action of other exogenous cannabinergic ligands that are administered in order to elicit a cannabinergic response.

Liquid Crystalline Properties of Cholesteryl ω-Arylalkanoates

The thermal properties of the homologous series of cholesteryl ω-(4-benzoylphenyl)- (I), ω-(4-benzylphenyl)- (II), ω-benzoyl- (III), and ω-phenoxyalkanoate (IV) have been investigated.For series I and II the cholesteric-isotropic (Ch-I) transition temperatures, enthalpies, and entropies show a remarkable alternation.For series III and IV, the transition temperatures, enthalpies, and entropies exhibit weak alternation and their trends are opposite to those for series I and II, and the cholesteryl ω-phenylalkanoates.The cholesteric-isotropic transition temperatures are discussed in terms of the geometrical and electrical alternations stemming from the terminal aryl groups, and also the relative importance between these two terms.

Pseudo One-Step Cleavage of C-C Bonds in the Decomposition of Ionized Carboxyclic Acids. Radical Like Reactions in Mass Spectrometry

Metastable molecular ions of hexanoic acid (1) decompose unimolecularly to C2H5. and protonated methacrylic acid (5-H+)(92percent rel. abund.).Investigation of the mechanism reveals that 1) the branched cation radical 11 must be regarded as the essential intermediate in the course of the rearrangement/dissociation reaction and 2) the process commences with intramolecular hydrogen transfer from either C-3 or C-5 to the ionized carbonyl oxygen ("hidden" hydrogen migration).Hydrogen transfer from C-4, which would correspond to the well-known McLafferty rearrangement, is of no importance in the C2H5.-elimination from 1.The same conclusion applies for various alternative mechanisms, as for example a SRi type reaction, 1 -> 2-H+.The gas phase chemistry of the cation radical of 1, and in particular the hydrogen exchange processes between the methylene groups C-2/C-3 and C-5/C-6, is in surprisingly close correspondence to the chemistry of free alkyl radicals. - The syntheses of various 13C and 2H-labelled model compounds are described.