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Ethyl 3-ethoxy-3-iminopropionate hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2318-25-4 Structure
  • Basic information

    1. Product Name: Ethyl 3-ethoxy-3-iminopropionate hydrochloride
    2. Synonyms: propanoicacid,3-ethoxy-3-imino-,ethylester,hydrochloride;3-ETHOXY-3-IMINOPROPANOIC ACID ETHYL ESTER HYDROCHLORIDE;3-ETHOXY-3-IMINOPROPIONIC ACID ETHYL ESTER HCL;3-ETHOXY-3-IMINOPROPIONIC ACID ETHYL ESTER HYDROCHLORIDE;DIETHYL MALONMONOIMIDATE HYDROCHLORIDE;IMINOESTERCHLOROHYDRATE;ETHYL 3-ETHOXY-3-IMINOPROPIONATE HYDROCHLORIDE;ETHYL-MONO-IMIDO-MALONATE HCL
    3. CAS NO:2318-25-4
    4. Molecular Formula: C7H13NO3*ClH
    5. Molecular Weight: 195.64
    6. EINECS: 219-028-1
    7. Product Categories: N/A
    8. Mol File: 2318-25-4.mol
  • Chemical Properties

    1. Melting Point: 111-113 °C (decomp)
    2. Boiling Point: 185.7°Cat760mmHg
    3. Flash Point: 66.1°C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 0.688mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: Ethyl 3-ethoxy-3-iminopropionate hydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: Ethyl 3-ethoxy-3-iminopropionate hydrochloride(2318-25-4)
    12. EPA Substance Registry System: Ethyl 3-ethoxy-3-iminopropionate hydrochloride(2318-25-4)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. F: 10-21
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 2318-25-4(Hazardous Substances Data)

2318-25-4 Usage

Chemical Properties

White crystalline powder

Check Digit Verification of cas no

The CAS Registry Mumber 2318-25-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,1 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2318-25:
(6*2)+(5*3)+(4*1)+(3*8)+(2*2)+(1*5)=64
64 % 10 = 4
So 2318-25-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO3.ClH/c1-3-10-6(8)5-7(9)11-4-2;/h8H,3-5H2,1-2H3;1H

2318-25-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 3-ethoxy-3-iminopropanoate,hydrochloride

1.2 Other means of identification

Product number -
Other names 3-ethoxy-3-iminopropionic acid ethyl ester hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2318-25-4 SDS

2318-25-4Relevant articles and documents

Synthesis of α-substituted 2-(1H-1,2,4-triazol-3-yl)acetates and 5-amino-2,4-dihydro-3H-pyrazol-3-ones via the Pinner strategy

Khomenko, Dmytro M.,Doroshchuk, Roman O.,Ivanova, Hanna V.,Zakharchenko, Borys V.,Raspertova, Ilona V.,Vaschenko, Oleksandr V.,Shova, Sergiu,Dobrydnev, Alexey V.,Moroz, Yurii S.,Grygorenko, Oleksandr O.,Lampeka, Rostyslav D.

supporting information, (2021/03/17)

A series of 2-(1H-1,2,4-triazol-3-yl)acetates, as well as 4-mono- and 4,4-disubstituted 5-amino-2,4-dihydro-3H-pyrazol-3-ones (including spirocyclic derivatives) have been synthesized using the Pinner reaction strategy. α-Mono- and α,α-disubstituted ethyl cyanoacetates were converted into the corresponding carboxyimidate salts that served as the key intermediates. Their further reaction with formylhydrazide or hydrazine hydrate provided triazolylacetates or aminopyrazolones (including spirocyclic derivatives), depending on the structure of the starting Pinner salt and the nature of the nucleophile. The scope and limitations of the developed synthetic method have been established.

Preparation method of di-tert-butyl-2-(2-ethoxy-2-oxymethyleneethyl)dihydro-3H-imidazopyridine dicarboxylate

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Paragraph 0007; 0008, (2020/09/12)

The invention relates to a preparation method of di-tert-butyl-2-(2-ethoxy-2-oxymethyleneethyl)dihydro-3H-imidazopyridine dicarboxylate, and mainly solves the technical problem that no suitable industrial synthesis method is available at present. The method comprises the following three steps: 1, adding ethanol into methyl tert-butyl ether into which saturated hydrochloric acid gas is introduced,and reacting a compound 1 with ethanol to obtain a compound 2; 2, reacting the compound 2 with 3,4-diaminopyridine in ethyl alcohol, concentrating, and reacting the obtained crude product in glacial acetic acid to obtain a compound 3, and 3, reacting the compound 3 with palladium carbon and Boc anhydride in ethyl alcohol to obtain a final compound 4, wherein the reaction formula is shown in the specification.

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

-

Paragraph 0150; 0428-0429, (2020/08/30)

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

Pyridine triazole modified coumarin Cu2 + The preparation method of the fluorescent probe (by machine translation)

-

Paragraph 0013; 0036; 0041-0042; 0049; 0053-0054, (2019/04/17)

Pyridine triazole modified coumarin Cu2 + fluorescent probe preparation method, the invention relates to a triazole modified coumarin Cu pyridine2 + Fluorescent probe is 3 - formyl - 7 - (diethylamino) coumarin Schiff base, the preparation method comprises preparing a compound (A), compound (B) and compound (C) 3 - formyl - 7 - (diethylamino) coumarin Schiff base three steps. 3 - Formyl - 7 - (diethylamino) coumarin Schiff base as a fluorescent probe in the detection of copper, has good light stability, high fluorescence quantum yield, storck large displacement and the like, can be fast, efficient, single-minded identification in an aqueous solution of copper ion, which is a fast high sensitivity fluorescence probe, other common metal ion has a stronger anti-interference capability, real-time monitoring and detecting the stability is high, can be used for qualitative, quantitative detection environment in the copper ion, to the cupric ion detection has very good application value. The reaction of the invention easy control of the condition, the operation is convenient, and the yield is high. (by machine translation)

Energetic compounds featuring bi(1,3,4-oxadiazole): a new family of insensitive energetic materials

Tian, Jiawei,Xiong, Hualin,Lin, Qiuhan,Cheng, Guangbin,Yang, Hongwei

, p. 1918 - 1924 (2017/03/09)

In this contribution, 5,5′-bis(trinitromethyl)-2,2′-bi(1,3,4-oxadiazole) (4) and 11 nitrogen-rich salts featuring bi(1,3,4-oxadiazole) were synthesised. Compound 4 was obtained by nitration of 2,2′-bi(1,3,4-oxadiazolyl)-5,5′-diacetic acid and the salts (6, 8-17) were prepared by facile deprotonation and metathesis reactions. All compounds were characterized by IR, multinuclear NMR spectroscopy and elemental analysis. The structures of 6, 9 and 15 were further confirmed by single crystal X-ray diffraction. The physicochemical as well as energetic properties of these compounds including density, thermal stability and sensitivity were investigated. Except for 12 and 15, most of the salts decompose at temperatures over 180 °C. The performance data from the calculated heats of formation and experimental densities indicate that many of the salts have potential applications as energetic materials. The tested sensitivities of these compounds illustrate that they are less sensitive than RDX towards impact, friction and electrostatic discharge.

REMOVAL OF SENESCENCE-ASSOCIATED MACROPHAGES

-

Paragraph 0341; 0342, (2017/12/15)

In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging and/or age-related diseases.

A New Synthesis of 2-Aminoindoles and 6-Aminopyrrolo[3,2- d ]pyrimidines from π-Deficient 1,2-Dihaloarenes and Geminal Enediamines

Mishina, Maria S.,Ivanov, Alexander Yu.,Lobanov, Pavel S.,Dar'In, Dmitrii V.

supporting information, p. 2851 - 2862 (2016/08/30)

An efficient approach for the synthesis of fused 2-aminopyrroles via geminal enediamines and π-deficient 1,2-dihaloarenes is presented. The two-step methodology includes aromatic nucleophilic substitution of the activated halogen of dihaloarene with enediamine C-nucleophilic center followed by Cu-catalyzed intramolecular N-arylation. This approach allows access to a variety of 2-amino-6-nitroindoles and 6-aminopyrrolo[3,2-d]pyrimidines (including N-mono- and N,N-disubstituted) in moderate and good yields under mild conditions.

Tetranuclear Zn(II) and mononuclear Ni(II) based coordination polymers derived from a pair of isomeric 1,2,4-triazole ligands 3,5-disubstituted by pyridine and acetate ethyl ester groups

Hu, Bin,Wang, Yue-Hua,Qian, Hui-Fen,Peng, Yu-Xin,Huang, Wei

, p. 138 - 143 (2016/02/03)

A pair of isomeric compounds, namely L1-Et [2-(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)acetate ethyl ester] and L3-Et [2-(5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)acetate ethyl ester], has been synthesized in this work, and they are used as multi-dentate ligands to react with certain transition-metal ions under solvothermal conditions. As a result, two three-dimensional (3D) coordination polymers, i.e. {[Zn(L1)(H2O)]ClO4·2H2O·0.5MeOH}n (C1) and {[Ni(L2)2](ClO4)2·2H2O}n (C3), have been yielded and structurally characterized, where ligand L2 is found to be the decomposition product of ligand L3-Et. It is noted that a novel tetranuclear Zn4(L1)4 based cluster-organic framework is constructed in the case of C1 exhibiting a three-dimensional (3D) 2-fold interpenetrating diamond structure. By comparing the structures of C1 and C3, it is concluded that the competition between metal-ion complexation and ligand decomposition leads to the formation of different coordination polymers.

Oxidation strategy for the synthesis of regioisomeric spiroisobenzofuranopyrroles: Facile entries to spiro[isobenzofuran-1,2′-pyrrole] and Spiro[isobenzofuran-1,3′-pyrrole] derivatives

Fan, Yefeng,Liu, Song,Chen, Nanyang,Shao, Xusheng,Xu, Xiaoyong,Li, Zhong

supporting information, p. 393 - 403 (2015/02/19)

Two practical and efficient approaches have been developed to synthesize two kinds of racemic spiroisobenzofuranopyrrole analogues as regioisomers. In the presence of sodium periodate, cis-indeno[1,2-b]pyrrol-4(1H)-ones were converted into spiro[isobenzofuran-1,2′-pyrrole] derivatives by a two-step process. In addition, oxidative reactions promoted by lead tetraacetate were demonstrated using cis-indeno[2,1-b]pyrrol-8(1H)-ones as substrates, affording spiro[isobenzofuran-1,3′-pyrrole] derivatives. The remarkable features of two approaches included mild and convenient reaction conditions, a broad substrate scope, and moderate to excellent yields. Possible mechanisms were proposed based on the comparison of the intermediates and products.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

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Paragraph 0413, (2015/06/25)

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

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