27317-59-5

Usage

Uses

Used in Organic Synthesis:
Ethyl 3-ethoxy-3-iminopropionate is utilized as a building block in organic synthesis for the preparation of a range of pharmaceuticals and agrochemicals. Its unique structure allows it to be a versatile component in the creation of complex organic molecules.
Used in Fine Chemicals Production:
ethyl 3-ethoxy-3-iminopropionate also serves as a reagent in the production of fine chemicals and specialty materials, where its specific properties can be leveraged to achieve desired outcomes in chemical reactions.
Used in Medicinal Chemistry:
Ethyl 3-ethoxy-3-iminopropionate has potential applications in the field of medicinal chemistry, where it acts as a precursor for the design and synthesis of small molecule drugs. These drugs can be tailored to target specific biological pathways, offering new avenues for therapeutic intervention.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ethyl 3-ethoxy-3-iminopropionate is used as a key intermediate for the synthesis of various drug molecules, contributing to the development of new medications that address unmet medical needs.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, ethyl 3-ethoxy-3-iminopropionate is employed as an intermediate in the synthesis of pesticides and other agrochemical products, enhancing crop protection and yield.

InChI:InChI=1/C7H13NO3/c1-3-10-6(8)5-7(9)11-4-2/h8H,3-5H2,1-2H3/b8-6-

Upstream product

• 64-17-5 ethanol 
• 105-56-6 ethyl 2-cyanoacetate 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 

Downstream Products

• 70959-85-2 ethyl 2-amino-6-methylnicotinate 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 735211-22-0 3-amino-3-phenylhydrazono-propionic acid ethyl ester 
• 99981-90-5 2-amino-4,5,6-trimethyl-nicotinic acid ethyl ester 
• 67960-36-5 ethyl 2-amino-5,6,7,8-tetrahydroquinoline-3-carboxylate 
• 82417-99-0 2-Amino-4-methyl-6-phenyl-3-pyridincarbonsaeure-ethylester 
• 56162-64-2 Ethyl 2-Amino-6-phenyl-3-pyridinecarboxylate 
• 34570-17-7 malonamamidine hydrochloride 
• 1163-69-5 3-ethoxy-5-phenoxycarbonylamino-isothiazole-4-carboxylic acid ethyl ester 
• 79106-26-6 ethyl 3-amino-3-<4-(4-chlorophenyl)piperazino>propenoate 
• 63012-90-8 7-amino-2,3-dihydro-5H-thiazolo<3,2-a>-pyrimidin-5-one 
• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 21418-71-3 ethyl 2-(imidazolidin-2-ylidene)acetate 
• 120671-12-7 1-benzyl-2-(ethoxycarbonylmethylene)-2,3,4,5-tetrahydroimidazole 

Relevant academic research and scientific papers

The structure modification of seven-membered aza-brigded neonicotinoids in order to investigate their impact on honey bees

In order to explore the relationship between the structure and the toxicity to honey bees of seven-membered aza-bridged neonicotinoids, 16 novel seven-membered aza-bridged neonicotinoid analogues are synthesized by replacing the pyridine ring, and changing the substituents on the pyridine ring, the electron-withdrawing group NO2 and the imidazole ring of our previously developed aza-bridged neonicotinoid 1-[(6-chloropyridin-3-yl)methyl)]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epiminoimidazo azepine (C-29). The insecticidal bioactivities against cowpea aphid (Aphis craccivora) and the bee toxicities of these compounds are tested. Some of the title compounds present good insecticidal activities against cowpea aphid. The results also show that some of the title compounds exhibit lower bee toxicity than that of C-29 and imidacloprid. This suggests that changing the substituents on the neonicotinoids can influence the toxicity toward honey bees of these analogues.

A New Synthesis of 2-Aminoindoles and 6-Aminopyrrolo[3,2- d ]pyrimidines from π-Deficient 1,2-Dihaloarenes and Geminal Enediamines

An efficient approach for the synthesis of fused 2-aminopyrroles via geminal enediamines and π-deficient 1,2-dihaloarenes is presented. The two-step methodology includes aromatic nucleophilic substitution of the activated halogen of dihaloarene with enediamine C-nucleophilic center followed by Cu-catalyzed intramolecular N-arylation. This approach allows access to a variety of 2-amino-6-nitroindoles and 6-aminopyrrolo[3,2-d]pyrimidines (including N-mono- and N,N-disubstituted) in moderate and good yields under mild conditions.

Microwave-Assisted Bohlmann-Rahtz Synthesis of Highly Substituted 2-Aminonicotinates

Microwave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 hours facilitated Bohlmann-Rahtz pyridine synthesis to give highly substituted ethyl 2-aminonicotinates with total regiocontrol and in reasonable to excellent yield, following purification by immobilization upon an acidic resin.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

SUBSTITUTED HYDRAZIDE COMPOUNDS AND USE THEREOF

The invention relates to substituted hydrazide compounds as shown by general formula I, including geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and use of the same, wherein the substitutents Ar and R have the same meanings as given in the Description. The invention further relates to the use of compounds of general formula I in the preparation of medicament for the treatment and/or prevention of cancer and other proliferative diseases.

SUBSTITUTED HYDRAZIDE COMPOUNDS AND APPLICATION THEREOF

The invention relates to substituted hydrazide compounds as shown by general formula I, including geometrical isomers, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and use of the same, wherein the substitutents Ar and R having the same meanings as given in the Description. T The invention further relates to the use of compounds of general formula I in the preparation of medicament for the treatment and/or prevention of cancer and other proliferative diseases.

Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines

A series of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines have been synthesised, characterised and tested for their in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity. The compounds were prepared from ethyl cyanoacetate and α-bromoacetophenones via the 2-amino-3-ethoxycarbonyl-5- aryl-pyrroles and 4-chloro-6-arylpyrrolopyrimidines. Aromatic substitution with benzylic amines was performed by conventional thermal substitution, and palladium catalysed coupling. The two methods resulted in similar yields, but the palladium coupling had the benefit of lower chemical consumption and reduced reaction times. Eight of the new compounds had IC50 values in the range of 2.8-9.0 nM. Four of these have a fluorine atom positioned at sites otherwise potentially susceptible to oxidative metabolism. Structural variation of the 6-aryl group indicated that the inhibitory action was only moderately sensitive to modifications in this fragment. However, the potency depended strongly on the structure of the aromatic part of the 4-amino group, and any aromatic substitution except fluorine reduced the in vitro activity. The cellular EGFR internalization response of selected compounds was evaluated using HeLa cells. Three fluorinated derivatives had a pronounced effect in inhibiting EGFR internalization.

FUSED BICYCLIC PYRIMIDINES AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to fused bicyclic pyrimidine containing zinc- binding moiety based derivatives that have unique properties as protein tyrosine kinase (PTK) inhibitors and their use in the treatment of PTK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS

The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.

TRIAZOLOPYRIDINE DERIVATIVES AS HERBICIDES

Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.