A practical manufacturing synthesis of 1-(R)-hydroxymethyl-DTPA: An important intermediate in the synthesis of MRI contrast agents
An efficient synthesis of alcohol 2 is described from L-Serine (OMe) in four synthetic steps. The process uses readily available reagents and is suitable for manufacturing.
Amedio Jr., John C.,Bernard, Paul J.,Fountain, Mark,Van Wagenen Jr., Gerritt
PROCESS FOR MANUFACTURE OF GADOFOSVESET TRISODIUM MONOHYDRATE
This application relates to a process for making a pharmaceutically acceptable formulation of gadofosveset trisodium monohydrate, wherein the process uses no more than one chromatographic purification for removal of impurities.
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Page/Page column 15; 16
(2014/10/15)
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