23610-05-1

Basic information

• Product Name: 4-[(Z)-Amino(hydroxyimino)methyl]benzoic acid
• Synonyms: 4-[(Z)-Amino(hydroxyimino)methyl]benzoic acid
• CAS NO: 23610-05-1
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16072
• Mol File: 23610-05-1.mol

Chemical Properties

• Melting Point: 228 °C (decomp)
• Boiling Point: 374.8±44.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 3.28±0.10(Predicted)
• CAS DataBase Reference: 4-[(Z)-Amino(hydroxyimino)methyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(Z)-Amino(hydroxyimino)methyl]benzoic acid(23610-05-1)
• EPA Substance Registry System: 4-[(Z)-Amino(hydroxyimino)methyl]benzoic acid(23610-05-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23610-05-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Z-AHMB is utilized as an antioxidant and anti-inflammatory agent for its potential to mitigate oxidative stress and inflammation, which are common pathological factors in various diseases.
Used in Cancer Treatment:
In the field of oncology, Z-AHMB is employed as a therapeutic agent for its potential to target cancer cells and inhibit their growth, making it a candidate for the treatment of various types of cancer.
Used in Inflammation Management:
Z-AHMB is used as an anti-inflammatory compound to manage conditions characterized by excessive inflammation, which can contribute to tissue damage and chronic diseases.
Used in Oxidative Stress Reduction:
As an antioxidant, Z-AHMB is applied to reduce oxidative stress, a condition implicated in the pathogenesis of numerous diseases and the aging process.
These applications highlight the versatility of Z-AHMB and its potential to contribute to the development of new therapeutic strategies across different areas of medicine.

Upstream product

• 619-65-8 4-cyanobenzoic Acid 
• 7732-18-5 water 
• 40069-10-1 4-hydroxycarbamimidoyl-benzoic acid ethyl ester 
• 104-85-8 para-methylbenzonitrile 
• 184778-33-4 methyl (Z)-4-(N’-hydroxycarbamimidoyl)benzoate 
• 1129-35-7 4-cyanobenzoic acid methyl ester 

Downstream Products

• 340736-76-7 4-[5-(trifluoromethyl)-1,.2,4-oxadiazol-3-yl]benzoic acid 
• 95124-68-8 5-methyl-3-(4-carboxyphenyl)-1,2,4-oxadiazole 
• 1418293-41-0 N-(2-(methylamino)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418293-54-5 tert-butyl methyl(2-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamido)ethyl)carbamate 
• 1418291-95-8 N-ethyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-13-3 N-(2-(dimethylamino)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-52-0 N-(2-methylpyridin-4-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-63-3 (R)-N-(1-(dimethylamino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-64-4 (S)-N-(1-(dimethylamino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 

Relevant articles and documents

Synthesis, Antifungal Activity, DFT Study and Molecular Dynamics Simulation of Novel 4-(1,2,4-Oxadiazol-3-yl)-N-(4-phenoxyphenyl)benzamide Derivatives

In order to find novel potential antifungal agrochemicals, a series of new 4-(1,2,4-oxadiazol-3-yl)-N-(4-phenoxyphenyl)benzamide derivatives 3a–j were designed, synthesized and characterized by their 1H-, 13C-NMR and HRMS spectra. Th

PREPARATION OF SUBSTITUTED 4-(N'-HYDROXYCARBAMIMIDOYL)BENZOIC ACIDS

The present invention relates to a process for the preparation of substituted 4-(N'-hydroxy- carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4- cyanobenzoic acids (Ila). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).

Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds

Starting from the structure of previously reported 3-Br-isoxazoline-based covalent inhibitors of P. falciparum glyceraldehyde 3-phosphate dehydrogenase, and with the intent to improve their metabolic stability and antimalarial activity, we designed and synthesized a series of simplified analogues that are characterized by the insertion of the oxadiazole ring as a bioisosteric replacement for the metabolically labile ester/amide function. We then further replaced the oxadiazole ring with a series of five-membered heterocycles and finally combined the most promising structural features. All the new derivatives were tested in vitro for antimalarial as well as antileishmanial activity. We identified two very promising new lead compounds, endowed with submicromolar antileishmanial activity and nanomolar antiplasmodial activity, respectively, and a very high selectivity index with respect to mammalian cells.

Substituted Oxadiazoles for Combating Phytopathogenic Fungi

The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof; and to their use for controlling phytopathogenic fungi; and to a method for combating phytopathogenic harmful

SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof, and the use thereof for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi,

USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to novel oxadiazoles of the formula I, or the N-oxides and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, or to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of the formula I and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of the formula I and to agrochemical compositions further comprising seeds. Formula (I).

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

Substituted oxadiazoles for combating phytopathogenic fungi The present invention relates to oxadiazoles of formula (I), or the N-oxides and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, and to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula (I), or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of formula I and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of formula I and to agrochemical compositions further comprising seeds.

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; to agrochemical compositions comprising at least one compound of the formula I; and to agrochemical compositions further comprising seeds.

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to novel trifluoromethyloxadiazoles of the formula (I), or an N-oxide, or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula (I), or an N-oxide, or an agriculturally acceptable salt thereof; to agrochemical compositions comprising at least one compound of the formula (I); and to agrochemical compositions further comprising seeds.

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to novel trifluoromethyl oxadiazoles of the formula (I), or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; to agrochemical compositions comprising at least one such compound; and to agrochemical compositions further comprising seeds.