340736-76-7

Usage

Uses

Used in Pharmaceutical Industry:
4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid is used as an intermediate in the synthesis of small molecule inhibitors for the HIV-1 gp41 protein. Its unique chemical structure allows it to play a crucial role in the development of new therapeutic agents targeting the fusion process of the HIV virus, which is essential for viral entry into host cells.
As an intermediate in the synthesis of HIV-1 gp41 inhibitors, 4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid contributes to the development of novel antiviral drugs that can potentially help in the treatment and management of HIV/AIDS. 4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid's specific properties enable it to be a valuable component in the design and synthesis of these inhibitors, offering new possibilities for combating the virus and improving the lives of those affected by the disease.

InChI:InChI=1/C10H5F3N2O3/c11-10(12,13)9-14-7(15-18-9)5-1-3-6(4-2-5)8(16)17/h1-4H,(H,16,17)

Upstream product

• 340736-74-5 methyl 4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoate 
• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 184778-33-4 methyl (Z)-4-(N’-hydroxycarbamimidoyl)benzoate 
• 407-25-0 trifluoroacetic anhydride 
• 23610-05-1 4-[(Z)-N’-hydroxycarbamimidoyl]benzoic acid 
• 23610-05-1 4-(N-hydroxycarbamimidoyl)-benzoic acid 
• 23610-05-1 4-[N’-hydroxycarbamimidoyl]benzoic acid 
• 354-32-5 trifluoracetyl chloride 
• 65695-05-8 methyl 4-(N’-hydroxycarbamimidoyl)benzoate 

Downstream Products

• 340736-48-3 methyl 2-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-1-[(2S)-3-(4-methoxyphenyl)-2-[[4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)benzoyl]amino]propanoyl]-3-oxopiperazinyl]acetate 
• 1418293-41-0 N-(2-(methylamino)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-64-4 (S)-N-(1-(dimethylamino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418291-95-8 N-ethyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-13-3 N-(2-(dimethylamino)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418292-52-0 N-(2-methylpyridin-4-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 1418293-54-5 tert-butyl methyl(2-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamido)ethyl)carbamate 
• 1418292-63-3 (R)-N-(1-(dimethylamino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 

Relevant academic research and scientific papers

PREPARATION OF AROMATIC CARBONYL COMPOUNDS BY CATALYTIC OXIDATION WITH MOLECULAR OXYGEN

The present invention relates to a process for the preparation of aromatic carbonyl compounds of formula I, which can be obtained through reaction of compounds of formula II with molecular oxygen in the presence of a solvent and a catalyst, which is composed of a cobalt(II) salt and N,N',N''-trihydroxyisocyanuric acid (THICA).

Synthesis, Antifungal Activity, DFT Study and Molecular Dynamics Simulation of Novel 4-(1,2,4-Oxadiazol-3-yl)-N-(4-phenoxyphenyl)benzamide Derivatives

In order to find novel potential antifungal agrochemicals, a series of new 4-(1,2,4-oxadiazol-3-yl)-N-(4-phenoxyphenyl)benzamide derivatives 3a–j were designed, synthesized and characterized by their 1H-, 13C-NMR and HRMS spectra. Th

Substituted Oxadiazoles for Combating Phytopathogenic Fungi

The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof; and to their use for controlling phytopathogenic fungi; and to a method for combating phytopathogenic harmful

SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof, and the use thereof for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi,

NOVEL OXADIAZOLES

The present invention relates to novel oxadiazoles of Formula I, wherein, R1, L1, A, L2 and R10 are as defined in the detailed description.

HETEROCYCLIC COMPOUNDS AS FUNGICIDES

The present invention relates to novel heterocyclic compound of Formula (I), (I) wherein, Het, L1, A, L2 and R12 are as defined in the detailed description, for use as fungicides.

PREPARATION OF SUBSTITUTED 3-ARYL-5-TRIFLUOROMETHYL-1,2,4-OXADIAZOLES

The present invention relates to a process for the preparation of 3-aryl-5-trifluoromethyl-1,2,4- oxadiazoles, which are useful as fungicidal compounds or as intermediates for the synthesis of fungicidal oxaciazole compounds, using trifluoroacetyl halides

USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to novel oxadiazoles of the formula I, or the N-oxides and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, or to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of the formula I and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of the formula I and to agrochemical compositions further comprising seeds. Formula (I).

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

Substituted oxadiazoles for combating phytopathogenic fungi The present invention relates to oxadiazoles of formula (I), or the N-oxides and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, and to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula (I), or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of formula I and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of formula I and to agrochemical compositions further comprising seeds.

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; to agrochemical compositions comprising at least one compound of the formula I; and to agrochemical compositions further comprising seeds.