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Methyl 4-bromo-5-methylthiophene-2-carboxylate is a chemical compound characterized by the molecular formula C7H7BrO2S. It is typically found as a brownish liquid and is known for its high boiling point and relative stability. These properties make it a valuable component in various complex chemical reactions, particularly in the field of organic synthesis.

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  • 237385-15-8 Structure
  • Basic information

    1. Product Name: Methyl 4-broMo-5-Methylthiophene-2-carboxylate
    2. Synonyms: Methyl 4-broMo-5-Methylthiophene-2-carboxylate;4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER
    3. CAS NO:237385-15-8
    4. Molecular Formula: C7H7BrO2S
    5. Molecular Weight: 235.09828
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 237385-15-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 277.1±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.575±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: Methyl 4-broMo-5-Methylthiophene-2-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Methyl 4-broMo-5-Methylthiophene-2-carboxylate(237385-15-8)
    11. EPA Substance Registry System: Methyl 4-broMo-5-Methylthiophene-2-carboxylate(237385-15-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 237385-15-8(Hazardous Substances Data)

237385-15-8 Usage

Uses

Used in Organic Synthesis:
Methyl 4-bromo-5-methylthiophene-2-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals and chemicals. Its unique structure and reactivity contribute to the development of new compounds with potential applications in medicine and other industries.
Used in Pharmaceutical Production:
In the pharmaceutical industry, Methyl 4-bromo-5-methylthiophene-2-carboxylate is utilized as a building block for the creation of novel drug molecules. Its incorporation into these molecules can enhance their therapeutic properties, leading to the development of more effective treatments for various diseases and conditions.
Safety Precautions:
Due to its reactive nature and potential hazardous impact on human health and the environment, it is crucial to follow proper safety precautions when handling and disposing of Methyl 4-bromo-5-methylthiophene-2-carboxylate. This includes the use of appropriate personal protective equipment, working in well-ventilated areas, and adhering to established disposal protocols.

Check Digit Verification of cas no

The CAS Registry Mumber 237385-15-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,7,3,8 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 237385-15:
(8*2)+(7*3)+(6*7)+(5*3)+(4*8)+(3*5)+(2*1)+(1*5)=148
148 % 10 = 8
So 237385-15-8 is a valid CAS Registry Number.

237385-15-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 4-bromo-5-methylthiophene-2-carboxylate

1.2 Other means of identification

Product number -
Other names methyl 4-bromo-5-methyl-2-thiophenecarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:237385-15-8 SDS

237385-15-8Downstream Products

237385-15-8Relevant articles and documents

PKB inhibitor

-

, (2021/03/13)

The invention provides a PKB inhibitor, particularly relates to a compound shown as a formula I or a pharmaceutically acceptable salt thereof. The invention further provides a preparation method of the compound.

THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF

-

Page/Page column 239, (2016/01/25)

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides

Milner, Phillip J.,Yang, Yang,Buchwald, Stephen L.

supporting information, p. 4775 - 4780 (2015/10/28)

A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is

INHIBITORS OF AKT ACTIVITY

-

Page/Page column 37, (2010/09/03)

Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS

-

Page/Page column 31, (2010/08/08)

The invention encompasses imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS

-

Page/Page column 45, (2010/04/03)

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES

-

Page/Page column 89; 26, (2009/03/07)

Compounds of the following formula (I) are inhibitors of microtubule affinity regulating kinase, and hence find use in the treatment of neurodegenerative diseases associated with hyperphosphorylation of tau.

INTEGRASE INHIBITORS 3

-

Page/Page column 57, (2008/06/13)

The present invention provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Compounds of formula (I) are also provided.

Compounds and compositons for treating C1s-mediated diseases and conditions

-

, (2008/06/13)

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.

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