237435-80-2

Basic information

• Product Name: 2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine
• Synonyms: 2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine
• CAS NO: 237435-80-2
• Molecular Formula: C₁₂H₇Cl₂N₃
• Molecular Weight: 264.11008
• Mol File: 237435-80-2.mol

Chemical Properties

• Boiling Point: 433.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.487±0.06 g/cm3(Predicted)
• PKA: 10.46±0.40(Predicted)
• CAS DataBase Reference: 2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine(237435-80-2)
• EPA Substance Registry System: 2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine(237435-80-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 237435-80-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine is utilized as a key intermediate in the synthesis of various pharmaceuticals due to its unique structure and properties. It serves as a valuable component in the development of novel drugs, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the realm of organic synthesis, 2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine is employed as a versatile building block. Its reactivity and structural features make it suitable for the creation of a wide array of organic compounds, including those with potential applications in various industries beyond pharmaceuticals.
Used in Research and Development:
2,4-dichloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine is also used as a subject of interest in research and development settings. Its exploration in medicinal applications and its potential to contribute to the discovery of new therapeutic agents make it a significant focus for scientists and researchers working in drug development and related fields.

Upstream product

• 34771-39-6 6-phenylpyrrolo[3,2-d]pyrimidine-2,4-diol 
• 614-16-4 Benzoylacetonitrile 
• 237435-26-6 2-cyano-1-phenylvinyl-4-methylbenzenesulfonate 
• 237435-27-7 ethyl 3-amino-5-phenyl-1H-pyrrole-2-carboxylate 

Downstream Products

• 237435-81-3 2-chloro-6-phenyl-4-piperidylpyrrolo[3,2-d]pyrimidine 

Relevant articles and documents

Compounds and methods which modulate feeding behavior and related diseases

There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.

Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacological data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist might be a useful therapeutic agent for the treatment of obesity. In attempts to identify potential Y5 antagonists, a series of pyrrolo[3,2-d]pyrimidine derivatives was prepared and evaluated for their ability to bind to Y5 receptors in vitro. We report here the synthesis and initial structure-activity relationship investigations for this class of compounds. The target compounds were prepared by a variety of synthetic routes designed to modify both the substitution and the heterocyclic core of the pyrrolo[3,2-d]pyrimidine lead 1. In addition to identifying several potent Y5 antagonists for evaluation as potential antiobesity agents, a pharmacophore model for the human Y5 receptor is presented.