2379-98-8Relevant articles and documents
Mitochondria-Targeted Inhibitors of Cytochrome C Peroxidase for Protection from Apoptosis
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Paragraph 0263; 0264, (2013/08/15)
The present application is directed to novel imidazole-substituted fatty acids that have been functionalized with an alkyl triphenylphosphonium group, compositions comprising these compounds and their use as inhibitors of cytochrome c peroxidase, in particular for the treatment and prevention of apoptosis.
Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation
Ebert, Cynthia,Felluga, Fulvia,Forzato, Cristina,Foscato, Marco,Gardossi, Lucia,Nitti, Patrizia,Pitacco, Giuliana,Boga, Carla,Caruana, Paolo,Micheletti, Gabriele,Calonghi, Natalia,Masotti, Lanfranco
, p. 38 - 45 (2012/11/07)
Enantioenriched 7-, 8-, 9-, and 10-hydroxystearic acids (HSA) were obtained, for the first time, by kinetic resolution of their racemates with lipases CALB and PS, in the presence of vinyl acetate. Among them, the best results were obtained for 7-HSA and 9-HSA, whose enantiomeric excess was around 55%. The same resolutions carried out on the hydroxy esters completely failed. For the acid substrates neither the Kazlauskas' rule nor the 3D-QSAR model could be applied, since both models are focused on the CALB alcohol-pocket evaluation and not on the acyl-pocket one. Therefore, a semiquantitative approach was used, whose results were in accordance with our findings, as far as the absolute configuration of the product is concerned.
8-Hydroxyoctadec-10(Z)-enoic Acid in Diospyros montana Seed Oil
Rauf, Abdul,Ahmad, M. S.,Osman, S. M.
, p. 283 (2007/10/02)
The seed glycerides of Diospyros montana contain mainly C16 and C18 fatty acids and a hitherto unknown minor component (5.4percent) characterised as 8-hydroxyoctadec-10(Z)-enoic acid.
AN 8-HYDROXYOCTADECA-CIS-11,14-DIENOIC ACID FROM MIRABILIS JALAPA SEED OIL
Ahmad, Mohammad Shamim,Rauf, Abdul,Mustafa, Jamal,Osman, Sheikh Mohammad
, p. 2247 - 2250 (2007/10/02)
A fatty acid, found as a minor component in the seed oil of Mirabilis jalapa, is shown to be the hitherto unknown 8-hydroxyoctadeca-cis-11,14-dienoic acid. - Key Word Index: Mirabilis jalapa; Nyctaginaceae; seed oil; 8-hydroxyoctadeca-cis-11,14-dienoic acid.