- INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).
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- Organo-phosphoric esters and their production and use
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Phosphoro-thioates or dithioates of the formula (I), STR1 wherein R is a C1 -C3 alkyl group, R1 is a C1 -C3 alkoxy, C1 -C4 alkylamino or allylamino group, R2 is a halogen atom, a C1 -C4 alkoxy or C1 -C3 alkyl group, R3 is a hydrogen or halogen atom or a C1 -C3 alkyl group, R4 is a C1 -C3 alkyl group, and X is an oxygen or sulfur atom, provided that when R1 is a C1 -C4 alkylamino or allylamino group, X is an oxygen atom, a process for producing phosphoro-thioates or dithioates of the formula (I) characterized by condensing a pyrimidine of the formula (II), STR2 wherein Y is a halogen atom, and R2, R3 and R4 are as defined above, with a thio- or dithio-phosphate of the formula, STR3 wherein M is an alkali metal atom or an ammonium group, and R, R1 and X are as defined above, an insecticide, acaricide and nematocide characterized by containing phosphoro-thioates or dithioates of the formula (I) as an active ingredient, and pyrimidines, novel intermediate compounds, of the formula (II) wherein R2 is a C1 -C4 alkoxy group or a halogen atom, R3 is a hydrogen or halogen atom or a C1 -C3 alkyl group, and R4 is a C2 -C3 alkyl group.
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