- Cu(I)-catalyzed intramolecular cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions
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Novel, easy-to-perform and practical intramolecular Cu(I)-catalyzed cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions are reported. The isolated cyclized products under microwave conditions are obtained with high yields and with short reaction times offering a valuable and reliable alternative to other protocols for the synthesis of fluorene analogues.
- Haggam, Reda A.
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p. 6488 - 6494
(2013/07/26)
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- Novel syntheses of fluorenones via nitrile-directed palladium-catalyzed C-H and dual C-H bond activation
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Novel procedures for the [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H and dual C-H bond activation with insertion of nitrile were developed, which afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.
- Wan, Jung-Chih,Huang, Jun-Min,Jhan, Yu-Huei,Hsieh, Jen-Chieh
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supporting information
p. 2742 - 2745
(2013/07/19)
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- Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs
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Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells.
- Zeng, Wei,Eric Ballard,Tkachenko, Alexander G.,Burns, Virginia A.,Feldheim, Daniel L.,Melander, Christian
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p. 5148 - 5151
(2007/10/03)
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- An intramolecular arylation route to the kinafluorenones
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Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of kinafluorenone 2, providing an effective alternative to Friedel-Crafts-based approaches. (C) 2000 Elsevier Science Ltd.
- Qabaja, Ghassan,Jones, Graham B.
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p. 5317 - 5320
(2007/10/03)
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- Annulation strategies for benzo[b]fluorene synthesis: efficient routes to the kinafluorenone and WS-5995 antibiotics.
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Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative to Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.
- Qabaja,Jones
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p. 7187 - 7194
(2007/10/03)
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- An efficient synthesis of dihydroxyfluorenones via in situ Pd(0)-catalyzed cross-coupling
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All six dimethoxyfluorenones 6a-f and dihydroxyfluorenones 7a-f, wherein substitution occurs at only one aromatic ring, were conveniently prepared by palladium(0)-catalyzed cross-coupling reactions of aryl bromides/triflates 2a-e with in situ generated ar
- Ciske, Fred L.,Jones Jr., Winton D.
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p. 1195 - 1198
(2007/10/03)
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- A simple approach to the synthesis of fluoren-9-ones
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Cyclohexene-1-Carboxylic acid (I) undergoes reaction with various aromatic substrates (2a-i) in presence of polyphosphoric acid (PPA) at 100°C to give cis-1,2,3,4,4a,9a-hexahydrofluoren-9-ones (3a-i) in good yield. Dehydrogenation of (3a-i) with selenium powder afforded corresponding fluoren-9-ones (4a-i) in high yield.
- Ramana,Potnis
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p. 1751 - 1760
(2007/10/02)
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- A new and simple synthesis of fluoren-9-ones
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Ethyl cyclohexene-1-carboxylate (1) undergoes reaction with various aromatic substrates in presence of concentrated sulfuric acid to give cis-1,2,3,4,4a,9a-hexahydrofluoren-9-ones 3a-f which on dehydrogenation afforded the corresponding fluoren-9-ones 4a-f in good yield. Fluorenones with an alkoxy group in the meta-orientation with respect to carbonyl group have also been prepared.
- Ramana,Potnis
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p. 575 - 576
(2007/10/02)
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