Metal-Free Hydroxymethylation of Indole Derivatives with Formic Acid as an Alternative Way to Indirect Utilization of CO2
The selective N-alkylation of indole substrates remains an ongoing research challenge for the relative attenuated nucleophilicity toward nitrogen. Herein, we developed the hydroxymethylation of indole derivatives to afford N-alkylated indole products with
Huang, Wen-Bin,Yang, Meng,He, Liang-Nian
p. 3775 - 3779
(2022/02/10)
Solvent-free N-hydroxymethylation using formalin over basic alumina
A convenient and high yield method for N-hydroxymethylation of amines with formalin over basic alumina under solvent-free conditions with microwave heating is described.
Gupta, Rajive,Paul, Satya,Nanda, Puja
p. 573 - 574
(2007/10/03)
Synthesis of some N-substituted carbazoles and their larvicidal studies
Some N-substituted carbazoles have been synthesized and a comparative larvicidal study has also been done on the larvae of Culex quinquefasciatus.
Das,Begum,Choudhury,Banerji
p. 158 - 160
(2007/10/03)
Gas-phase cyclisation reactions of 1-(2-arylaminophenyl)alkaniminyl radicals
Flash vacuum pyrolysis (FVP) of the oxime ethers 9-11 at 650°C (10-2-10-3 Torr) gives products such as the nitrile 17, carbazoles 19 and 20 and acridines 18 and 21 derived from the corresponding iminyl radicals 13-15. The mechanism proposed for the formation of the acridines involves a key hydrogen abstraction by the iminyl of the adjacent N-H atom. When this route is blocked by an N-methyl group, as in 12, alternative cyclisations ensue, yielding the dihydroquinazoline 26 (via another hydrogen abstraction process) and the benzimidazole 25 (via an iminyl-imidoyl interconversion).
Leardini, Rino,McNab, Hamish,Nanni, Daniele,Parsons, Simon,Reed, David,Tenan, Anton G.
p. 1833 - 1838
(2007/10/03)
Model Systems for Cytochrome P450-dependent Mono-oxygenases. Part 5. Amine Oxidation. Part 17. Oxidative N-Dealkylation of Tertiary Amines by Metalloporphyrin-catalysed Model Systems for Cytochrome P450 Monooxygenases
NN-Dimethylbenzylamine has been oxidatively demethylated to N-methylbenzylamine and debenzylated to benzaldehyde by iodosylbenzene and by t-butyl hydroperoxide catalysed by tetraphenylporphinato-iron(III) or -manganese(III) chloride.The influence of substituents on the aromatic ring and of deuteration of the benzylic hydrogens on the relative reactivity of the substrates and on the product distribution has been stidied.The results suggest that the initial step in the metalloporphyrin-catalysed iodosylbenzene oxidations is an electron-transfer from the amine to a high valent oxometal species, whereas, with t-butyl hydroperoxide the mechanism is one of hydrogen abstraction from the amine by the t-butoxyl radical.The mechanisms of the subsequent steps are discussed.
Smith, John R. Lindsay,Mortimer, David N.
p. 1743 - 1750
(2007/10/02)
Oxidative dealkylation of tertiary amines by iron(III) porphyrin-iodosoxylene system as a model of cytochrome P-450.
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Miyata,Kiuchi,Hirobe
p. 1489 - 1492
(2007/10/02)
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