241127-76-4

Basic information

• Product Name: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)- (9CI)
• Synonyms: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)- (9CI);2,2,2-trifluoro-1-(4-nitrophenyl)ethanol;1-(4-Nitrophenyl)-2,2,2-trifluoroethanol
• CAS NO: 241127-76-4
• Molecular Formula: C₈H₆F₃NO₃
• Molecular Weight: 221.1333496
• Product Categories: ACETYLHALIDE
• Mol File: 241127-76-4.mol

Chemical Properties

• Melting Point: 128-130 °C
• Boiling Point: 314.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.486±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 11.13±0.10(Predicted)
• CAS DataBase Reference: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)- (9CI)(241127-76-4)
• EPA Substance Registry System: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)- (9CI)(241127-76-4)

Safety Data

• Hazardous Substances Data: 241127-76-4(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 75-46-7 trifluoromethan 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 178042-35-8 1-(4-aminophenyl)-2,2,2-trifluoroethanol 
• 1135312-08-1 (R)-2,2,2-trifluoro-1-(4'-nitrophenyl)ethanol 
• 1135311-93-1 (S)-2,2,2-trifluoro-1-(4'-nitrophenyl)ethyl isobutyrate 
• 1135312-29-6 2,2,2-trifluoro-1-(4'-nitrophenyl)ethyl isobutyrate 
• 58808-61-0 α,α,α-trifluoro-4-nitroacetophenone 
• 144459-68-7 α,α-bis(trifluoromethyl)-4-nitrobenzylalkohol 

Relevant articles and documents

Fluorine-18 labelled Ruppert-Prakash reagent ([18F]Me3SiCF3) for the synthesis of 18F-trifluoromethylated compounds

This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [18F]Me3SiCF3. [18F]Me3SiCF3 was synthesized from [18F]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 m

Oxidation of α-trifluoromethyl and non-fluorinated alcohols: Via the merger of oxoammonium cations and photoredox catalysis

We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields.

FLUOROALKYLATING AGENT

Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R1 is a C1 to C8 fluoroalkyl group; R2 and R3 are each independently a C1 to C12 alkyl group or the like; Y1 to Y4 are each independently a hydrogen atom, a halogen atom, or the like; and X? is a monovalent anion. A compound of the general formula (3): R4—S—R1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R4—S—Z wherein R4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).

TYK2 INHIBITORS AND USES THEREOF

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A method of manufacturing a trifluoromethyl group-containing compound

PROBLEM TO BE SOLVED: To provide a method for producing a trifluoromethyl group-containing compound useful as a synthetic intermediate for a pharmaceutical or an agricultural chemical product.SOLUTION: There is provided a method for producing a trifluoromethyl group-containing compound represented by the following general formula (2) which is obtained by reacting a carbonyl compound having a specific structure with trifluoromethane and an organic base in an organic solvent (wherein, Rrepresents a methyl group, an ethyl group, a linear, branched or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, an ethenyl group, a 2-phenylethenyl group, a 9-anthryl group or a hetero ring; Rrepresents a hydrogen atom, a methyl group or a phenyl group.)

Flow trifluoromethylation of carbonyl compounds by Ruppert-Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

The Ruppert-Prakash reagent is the most powerful and well-documented reagent for trifluoromethylation. Despite its versatility, no general method exists for its use in a flow system. Here we report the first flow trifluoromethylation of carbonyl compounds

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Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(Diazo-2,2,2-trifluoroethyl)arenes

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