24460-74-0

Basic information

• Product Name: Lauryl chloroformate
• Synonyms: LAURYL CHLOROFORMATE;DODECYL CHLOROFORMATE;CHLOROFORMIC ACID LAURYL ESTER;CHLOROFORMIC ACID DODECYL ESTER;N-DODECYLCHLOROFORMATE;LAURYL CHLOROFORMATE 98%;LAURYLCHLOPOFORMATE;Chloridocarbonic acid dodecyl ester
• CAS NO: 24460-74-0
• Molecular Formula: C₁₃H₂₅ClO₂
• Molecular Weight: 248.79
• EINECS: 246-272-6
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks;Agrochemicals
• Mol File: 24460-74-0.mol

Chemical Properties

• Boiling Point: 168 °C / 20mmHg
• Flash Point: 230 °F
• Appearance: /
• Density: 0.922 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.33 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.442(lit.)
• CAS DataBase Reference: Lauryl chloroformate(CAS DataBase Reference)
• NIST Chemistry Reference: Lauryl chloroformate(24460-74-0)
• EPA Substance Registry System: Lauryl chloroformate(24460-74-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 24460-74-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Lauryl chloroformate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the formation of specific chemical bonds and structures essential in drug development.
Used in Agrochemical Industry:
In the agrochemical sector, lauryl chloroformate serves as an intermediate in the production of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Surfactant Production:
Lauryl chloroformate is utilized as a raw material in the manufacturing of surfactants, which are crucial in the formulation of detergents, cleaners, and other products that require emulsification or dispersion properties.
Used in Lubricant Industry:
As a component in the production of lubricants, lauryl chloroformate enhances the performance and longevity of these substances, providing essential properties such as reduced friction and wear.
Used in Coating Industry:
In the coatings industry, lauryl chloroformate is employed in the creation of various types of coatings, including those used in automotive, industrial, and consumer products, due to its ability to improve adhesion, durability, and other performance characteristics.
Due to the reactivity and potential hazards associated with lauryl chloroformate, it is imperative to handle and store this compound with extreme caution, adhering to proper safety measures to mitigate risks during its use in various applications.

InChI:InChI=1/C13H25ClO2/c1-2-3-4-5-6-7-8-9-10-11-12-16-13(14)15/h2-12H2,1H3

Upstream product

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Downstream Products

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Relevant articles and documents

Rotation about the Carbonyl Carbon-Nitrogen Bond in Micelles of N-(Dodecyloxycarbonyl)sarcosinate

The sodium salt of the title compound forms micelles readily, exhibiting a critical micelle concentration of 6 * 10-4 M at 25 deg C.Quasi-elastic light scattering shows that most of the micelles are approximately 6.0 nm in diameter, although indications of larger aggregates (ca.170 nm diameter) were also observed.These diameters do not change beyond experimental error over the temperature range 25-50 deg C.Proton NMR experiments were used to determine the kinetics of rotation about the carbonyl carbon-nitrogen bond of the detergent both in micelles and in the monomer.While ΔG for rotation was found to be independent of aggregation state, ΔH and ΔS for the process are substantially larger in the micelle.Variations in the activation parameters as the identity of the counterion is changed suggest that disruption of ionic interactions as the surface of the micelle is a part of the rotational process.

Unsaturated cyclic ureas as new nontoxic biodegradable transdermal penetration enhancers I: Synthesis

A new concept was implemented to reduce the toxicity of some new biodegradable transdermal penetration enhancers. These enhancers consist of 1-alkyl-4-imidazolin-2-one and a long-chain alkyl ester group at the N-3 position. The synthesis involves N-alkylation of the parent compound with soft alkylating agents which were prepared in high yields by an improved method. A phase transfer catalysis technique using KOH as the base, tetrabutylammonium bromide as the catalyst, and toluene as the solvent was found to be most effective in the N-alkylation step.

New mimics of the acetate function in pheromone-based attraction

Several analogues of (Z)-8-dodecenyl acetate (1a), the major pheromone component of the Oriental fruit moth, Cydia molesta, with chloroformate and lactone functional groups in place of the acetate moiety, were synthesized and investigated for their biological activity at four evaluation levels, i.e. by electroantennography (EAG), electrosensillography (ESG), short-range sexual stimulation and activation in the flight-tunnel. We found very strict requirements on the shape as well as on the electron distribution of the acetate group for a productive interaction with the receptor. The behavioral results showed that, among the analogues investigated, the chloroformate 1b, alken-4-olide 2a and also dodecyl acetate (1c) possess significant (60-85%) inhibitory activities. Based on electrophysiological evidence demonstrating that (i) only 1b is competing with the major pheromone component 1a for the same receptor sites on the male antennal sensilla, (ii) 1c elicits moderate EAG but no ESG responses and (iii) 2a does not produce any electrophysiological response at all, three possible inhibitory mechanisms by which these analogues are acting could be distinguished.

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formulae (I), (Ia), (II) and (IIa), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

Pyrene-derived novel one- and two-component organogelators

A new class of alkyl-chainappended pyrene derivatives 4 - 14 were synthesized and evaluated for their gelation abilities. Depending on the nature of the linking group, these compounds gelated a number of organic solvents, either in the presence or in the absence of the acceptor molecule 2,4,7-trinitrofluorenone (TNF). Compounds with ester, ether, or alkyl linkages gelated a number of hydroxylic and hydrocarbon solvents by means of a charge-transfer interaction with TNF, while compounds with amide, urethane and urea linkers formed gels on their own in a variety of solvents by means of π-π stacking and hydrogen-bonding interactions. The X-ray crystal structure of urethane (S)-12 showed hydrogen-bonding and stacking features, as suggested by the model. The gels obtained were investigated by spectroscopic and electron microscopic techniques which provided structural insights.

Sulfoethyl carbonate wetting agents and their use in detergent compositions

Carbonated isethionate surfactants, compositions containing them and methods for their preparation are disclosed.