- SYNTHESIS AND BROMINATION OF 8-METHYLQUINOLINE-5-CARBOXYLIC ACID
-
8-Methylquinoline-5-carboxylic acid was obtained by the Skraup reaction from 3-amino-p-toluic acid or by hydrolysis of 5-cyano-8-methylquinoline.The latter was synthesized by the Rosemund-von Braun reaction from 5-bromo-8-methylquinoline, which was obtained by bromination of 8-methylquinoline in the presence of silver sulfate.Bromination in the side chain of 8-methylquinoline-5-carboxylic acid and its nitrile was studied.
- Gracheva, I.N.,Tochilkin, A.I.
-
-
Read Online
- CASR AGONIST
-
By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
- -
-
Page/Page column 22
(2011/08/04)
-
- One step diazotization coupling process
-
A process for producing metal-free azo pigments in purely organic liquid or aqueous/organic liquid containing at most 10% of water calculated on the total weight of the suspension is described. In this one-step process, a suitable aromatic amine is diazotized without isolation of the obtained diazo compound and coupled with a coupling component. Both reactions are carried out in purely or essentially organic medium. The latter consists essentially of such amount of an organic liquid that a substantial portion either of the diazo component or of the coupling component or of both these reactants remain undissolved. Both reactants must be free from sulphonic acid groups. If the resulting azo pigment contains carboxylic acid groups, these can be subsequently converted to the corresponding amido or ester groups.
- -
-
-