60710-80-7

Basic information

• Product Name: 3-AMINO-4-METHYLBENZONITRILE
• Synonyms: 5-Cyano-2-methylaniline, 2-Amino-4-cyanotoluene;3-AMINO-4-METHYLBENZONITRILE;Benzonitrile, 3-amino-4-methyl-;2-Amino-4-cyanotoluene
• CAS NO: 60710-80-7
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16
• Product Categories: Aromatic Nitriles;Nitrile
• Mol File: 60710-80-7.mol

Chemical Properties

• Melting Point: 81 °C
• Boiling Point: 312.817°C at 760 mmHg
• Flash Point: 142.987°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2?+-.0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-4-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-METHYLBENZONITRILE(60710-80-7)
• EPA Substance Registry System: 3-AMINO-4-METHYLBENZONITRILE(60710-80-7)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 60710-80-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline

InChI:InChI=1/C8H8N2/c1-6-2-3-7(5-9)4-8(6)10/h2-4H,10H2,1H3

Upstream product

• 939-79-7 4-cyano-2-nitrotoluene 
• 90178-80-6 4-(chloromethyl)-3-nitrobenzonitrile 
• 74-90-8 hydrogen cyanide 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 39478-78-9 5-bromo-2-methylaniline 
• 557-21-1 dicyanozinc 
• 104-85-8 para-methylbenzonitrile 
• 874-86-2 4-cyanobenzyl chloride 
• 19406-86-1 3-Amino-4-methyl-benzamide 
• 2458-12-0 3-amino-p-toluic acid 

Downstream Products

• 2458-12-0 3-amino-p-toluic acid 
• 3816-66-8 3-hydroxy-4-methylbenzonitrile 
• 81018-31-7 3-acetylamino-4-methyl-benzonitrile 
• 42872-79-7 3-iodo-4-methylbenzonitrile 
• 188867-92-7 3-cyano-6-methylphenyl azide 
• 103261-68-3 5-cyano-2-methylbenzoic acid methyl ester 
• 450839-69-7 3-benzo[1,3]dioxol-5-yl-4-methylbenzonitrile 
• 450839-73-3 3-benzo[1,3]dioxol-5-yl-4-bromomethyl-benzonitrile 
• 450836-82-5 6-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-3'-methoxy(1,1'-biphenyl)-3-carbonitrile 
• 450844-38-9 5-[(4-cyano-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole 
• 421551-82-8 methyl 2-(bromomethyl)-5-cyanobenzoate 
• 450844-18-5 5-cyano-2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-yl)methoxymethyl]benzoic acid methyl ester 
• 450844-23-2 5-cyano-2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-yl)methoxymethyl]benzoic acid 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Transfer hydrogenation of nitroarenes into anilines by palladium nanoparticles via dehydrogenation of dimethylamine borane complex

This work reports a simple and highly efficient protocol for reduction of nitroarenes to corresponding amines via dehydrogenation of dimethylamine borane using palladium nanoparticle (Pd NPs) as a versatile heterogeneous catalyst. The facile approach for the synthesis of Pd NPs within 15 min in aqueous medium has been reported. The Pd NPs were well characterized using various analytical techniques such as XRD, FEG-SEM, TEM, EDAX and XPS. The developed catalytic system uses environmentally benign dimethylamine borane as a reducing agent which is highly stable, water soluble and nontoxic. The various amines were synthesized from nitroarenes in excellent yields within 10-60 min at room temperature. The catalyst was reused up to four successive cycles without significant loss in its catalytic activity.

Efficient cyanation of aryl bromides with K4[Fe(CN)6] catalyzed by a palladium-indolylphosphine complex

This study describes a general palladium-catalyzed cyanation of aryl bromides using K4[Fe(CN)6] as the cyanide surrogate. The reactions can be successfully conducted under mild reaction conditions (at 50 °C) in mixed solvents (water/MeCN = 1:1) without any surfactant additives, and afford the desired aryl nitriles in good-to-excellent yields. Particularly noteworthy is that this system allows the mildest reaction temperature reported so far for palladium-catalyzed cyanation of aryl bromides with K 4[Fe(CN)6] source in general. Common functional groups, including keto, aldehyde, free amine, and heterocyclic substrates are compatible under this system. Interestingly, the phosphine ligands bearing -PCy 2 moiety, which usually show excellent activity in aryl halide couplings, are found less effective than the corresponding ligands with -PPh2 group.

FUSED PYRIDINES ACTIVE AS INHIBITORS OF C-MET

Fused pyridines of formula (I) and the pharmaceutically acceptable salts thereof have activity as inhibitors of c-Met and may thus be used to treat various diseases and disorders including cancer. Processes for synthesizing the compounds are also described

IDENTIFICATION OF COMPOUNDS SUITABLE FOR TREATING AD

The invention provides a method of screening for compounds which inhibit the hyperphosphorylation of tau, and hence are suitable for treating AD and related conditions.

Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors

A novel series of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles have been synthesized as selective farnesyltransferase inhibitors using structure-based design. X-ray cocrystal structures of compound 20-FTase-HFP and A313326-

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.

Thrombin inhibitors, the preparation and use thereof

Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

Thrombin inhibitors

Thrombin inhibitors of the formula STR1 where R 1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described.The compounds I are suitable for controlling diseases.