Chemistry of Heterocyclic Compounds p. 275 - 277 (1980)
Update date:2022-08-16
Topics:
Gracheva, I.N.
Tochilkin, A.I.
8-Methylquinoline-5-carboxylic acid was obtained by the Skraup reaction from 3-amino-p-toluic acid or by hydrolysis of 5-cyano-8-methylquinoline.The latter was synthesized by the Rosemund-von Braun reaction from 5-bromo-8-methylquinoline, which was obtained by bromination of 8-methylquinoline in the presence of silver sulfate.Bromination in the side chain of 8-methylquinoline-5-carboxylic acid and its nitrile was studied.
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