24632-70-0

Basic information

• Product Name: 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide
• Synonyms: 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide;2-(4-BENZYLPIPERAZIN-1-YL)ACETOHYDRAZIDE;4-(Phenylmethyl)-1-piperazineacetic acid;4-Benzyl-1-piperazineacetic acid;4-(Phenylmethyl)-1-piperazineacetic acid,hydrazide;2-(4-benzylpiperazin-1-yl)acetic acid;4-Benzyl-1-piperazineacetic Acid Hydrazide
• CAS NO: 24632-70-0
• Molecular Formula: C₁₃H₂₀N₄O
• Molecular Weight: 248.3241
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 24632-70-0.mol

Chemical Properties

• Boiling Point: 443.496 °C at 760 mmHg
• Flash Point: 222.019 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 1.33E-06mmHg at 25°C
• Refractive Index: 1.573
• PKA: 13.37±0.37(Predicted)
• CAS DataBase Reference: 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide(24632-70-0)
• EPA Substance Registry System: 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide(24632-70-0)

Safety Data

• Hazardous Substances Data: 24632-70-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperazineacetic acid, 4-(phenylmethyl)-, hydrazide is used as an intermediate in the synthesis of PAC-1 (P132000), which is a caspase 3 activator. Caspase 3 is a crucial enzyme involved in the execution phase of apoptosis or programmed cell death. By activating caspase 3, PAC-1 can potentially induce apoptosis in cells, making it a valuable compound for the development of therapeutic agents targeting various diseases, including cancer.

InChI:InChI=1/C13H18N2O2/c16-13(17)11-15-8-6-14(7-9-15)10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H,16,17)

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 40004-08-8 1-(Ethoxycarbonylmethyl)piperazine 
• 100-44-7 benzyl chloride 
• 23173-76-4 ethyl 2-(4-benzylpiperazin-1-yl)acetate 

Downstream Products

• 1044929-62-5 2-(4-benzylpiperazin-1-yl)-N'-[(1E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene]acetohydrazide 
• 315183-08-5 de-allyl PAC-1 
• 315183-21-2 2-(4-benzylpiperazin-1-yl)-N-[(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]acetamide 
• 1075725-57-3 N'-(3-allyl-2-methoxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide 
• 1075725-59-5 C₂₀H₂₃N₇O₂ 
• 1075725-60-8 2-(4-benzylpiperazin-1-yl)-N'-(3,5-diallyl-2-hydroxybenzylidene)acetohydrazide 
• 315183-07-4 N'-(4-methoxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide 
• 315182-88-8 N'-(4-ethoxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide 
• 303106-00-5 N'-(3,4-dimethoxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide 
• 1449679-59-7 (E)-2-(4-benzylpiperazin-1-yl)-N'-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)acetohydrazide 
• 1449679-58-6 2-(4-benzylpiperazin-1-yl)-N'-(2-(bis(pyridin-2-ylmethyl)amino)acetyl)acetohydrazide 
• 1554476-07-1 N′-[[5-fluoro-2-hydroxy-3-(2-propenyl)phenyl]methylene]-4-(phenylmethyl)-1-piperazineacetohydrazide 
• 1554476-27-5 N′-[(5-fluoro-2-hydroxy-3-propylphenyl)methylene]-4-(phenylmethyl)-1-piperazineacetohydrazide 
• 315183-20-1 C₂₁H₂₆N₄O₂ 

Relevant articles and documents

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