Welcome to LookChem.com Sign In|Join Free

CAS

  • or
8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE, commonly known as lefetamine, is a psychoactive benzazepine compound that functions as a selective agonist for the dopamine D2 and D3 receptors. It has been the subject of research for its potential therapeutic applications in treating psychological and neurological disorders such as depression and Parkinson's disease. However, its use as a recreational drug due to its stimulant and hallucinogenic properties has led to its ban in several countries, citing concerns over abuse and health risks.

247133-22-8 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 247133-22-8 Structure
  • Basic information

    1. Product Name: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE
    2. Synonyms: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE;8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine
    3. CAS NO:247133-22-8
    4. Molecular Formula: C11H15NO
    5. Molecular Weight: 177.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 247133-22-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 297.6±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.018±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 9.89±0.20(Predicted)
    10. CAS DataBase Reference: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE(247133-22-8)
    12. EPA Substance Registry System: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE(247133-22-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 247133-22-8(Hazardous Substances Data)

247133-22-8 Usage

Uses

Used in Pharmaceutical Industry:
8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE is used as a therapeutic agent for the treatment of psychological disorders such as depression. Its agonistic action on dopamine D2 and D3 receptors is believed to contribute to its mood-enhancing effects, offering a potential alternative to traditional antidepressants.
Used in Neurological Treatment:
In the field of neurology, 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE is utilized for the management of Parkinson's disease. Its ability to selectively target dopamine receptors may help alleviate symptoms associated with this movement disorder, providing a novel approach to treatment.
Used in Recreational Drug Market (with caution):
Although not recommended due to its legal status and health risks, 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE has been used as a recreational drug for its stimulant and hallucinogenic effects. Its use in this context, however, is discouraged due to the potential for abuse and adverse health effects, leading to its ban in several countries.

Check Digit Verification of cas no

The CAS Registry Mumber 247133-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,7,1,3 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 247133-22:
(8*2)+(7*4)+(6*7)+(5*1)+(4*3)+(3*3)+(2*2)+(1*2)=118
118 % 10 = 8
So 247133-22-8 is a valid CAS Registry Number.

247133-22-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine

1.2 Other means of identification

Product number -
Other names 8-Methoxy-2,3,4,5-tetrahydro-1H

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:247133-22-8 SDS

247133-22-8Relevant articles and documents

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists

Luckhurst, Christopher A.,Ratcliffe, Marianne,Stein, Linda,Furber, Mark,Botterell, Sara,Laughton, David,Tomlinson, Wendy,Weaver, Richard,Chohan, Kamaldeep,Walding, Andrew

scheme or table, p. 531 - 536 (2011/02/27)

We describe the discovery of small molecule benzazepine derivatives as agonists of human peroxisome proliferator-activated receptor δ (PPARδ) that displayed excellent selectivity over the PPARα and PPARγ subtypes. Compound 8 displayed good PK in the rat a

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

-

Page/Page column 68, (2008/12/05)

Compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein X, R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

Ueno, Hiroshi,Yokota, Katsuyuki,Hoshi, Jun-Ichi,Yasue, Katsutaka,Hayashi, Mikio,Hase, Yasunori,Uchida, Itsuo,Aisaka, Kazuo,Katoh, Susumu,Cho, Hidetsura

, p. 3586 - 3604 (2007/10/03)

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine

Amidine compounds

-

, (2008/06/13)

A compound of the formula [I] wherein R1, R2and R3are the same or different and each is hydrogen atom, wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof. The compound of the presen

Synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepines via Pummerer-type cyclization of N-arylmethyl-N-(3-phenylsulfinylpropyl) formamides

Horiguchi, Yoshie,Saitoh, Toshiaki,Terakado, Sachiko,Honda, Konomi,Kimura, Tomoko,Toda, Jun,Sano, Takehiro

, p. 967 - 984 (2007/10/03)

A construction of 1H-benzazepine ring system was achieved via a modified Pummerer reaction of N-arylmethyl-N-(3-phenylsulfinylpropyl)-formamides (5) using trifluoroacetic acid and borontrifluoride etherate. This method provides an effective synthesis of 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-2-benzazepine (10a), the synthetic intermediate of capsazepine (1), an antagonist of capsaicin and resinferatoxin.

NITROGENOUS FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME

-

, (2008/06/13)

A nitrogen-containing condensed heterocyclic derivative of the present invention, which is a compound represented by the formula: wherein ring A represents benzene ring optionally having a further substituent, -L-represents -O-, -NR3a-, -S-, -SO-, -SO2-, -SO2NR3a-, -SO2NHCONR3a-, -SO2NHC(=NH)NR3a-, -C(=S)-, or -CONR3a- (wherein R3a and R3b represent independently hydrogen atom, cyano group, hydroxy group, amino group, a C1-6 alkyl group or a C1-6 alkoxy group), n represents an integer of 0 to 6, R is hydrogen atom or a hydrocarbon group optionally having a substituent, and may be different in repetition of n, R1 represents a hydrocarbon group optionally having a substituent or a group represented by the formula: (wherein R7 represents a hydrocarbon group optionally having a substituent), R2 represents hydrogen atom, an acyl group, a hydrocarbon group optionally having a substituent or a heterocyclic group optionally having a substituent, X represents a bond, O, S, SO, SO2 or NR4 (wherein R4 represents hydrogen atom, an acyl group or a hydrocarbon group optionally having a substituent), k and m represent independently an integer of 0 to 5, and 1k+m5, or a salt thereof, and the like, has an excellent thermal production promoting activity and the like, and is useful as an agent for preventing or treating obesity and obesity-based diseases.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 247133-22-8