- Synthesis method of 2,4,6-trifluorobenzylamine
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The invention relates to a synthesis method of 2,4,6-trifluorobenzylamine and mainly aims to solve the technical problem of lack of effective synthesis methods. The synthesis method comprises the following steps: continuously filling hydrogen chloride gas into a mixed solution with 1,3,5-trifluorobenzene, paraformaldehyde, ,sulfuric acid and acetic acid mixed solution of zinc chloride to generatea compound I; performing reaction on the compound I with urotropine to generate a quaternary ammonium salt compound II; and hydrolyzing the compound II in methyl alcohol and concentrated hydrochloricacid to generate a target compound III. The synthesis method is simple and few in steps, simple to operate, low in production cost, high in product purity and high in yield, and is suitable for industrial production.
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Paragraph 0005; 0008; 0010; 0011
(2018/10/27)
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- A 2, 4, 6- three fluorine animal pens method for the preparation of amine compounds
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The invention relates to a preparation method of a 2,4,6-trifluoro-benzylamine compound. The preparation method comprises the following steps: taking 1,3,5-trifluoro-benzene as a raw material, and preparing 2,4,6-trifluoro-benzylamine through lithiation, formylation, reduction, halogenation and replacement reaction. The reaction condition is mild, the operability is high, the atom economy is high, the technology is simple and easy to realize industrialization, and the product is high in purity and stable in quality, so that the compound accords with the using requirement of being as an intermediate.
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Paragraph 0058; 0059
(2017/01/23)
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