1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates
The development of imaging agents for in vivo detection of alpha-synuclein (α-syn) pathologies faces several challenges. A major gap in the field is the lack of diverse molecular scaffolds with high affinity and selectivity to α-syn fibrils for in vitro s
Sun, Xianwei,Admane, Prasad,Starosolski, Zbigniew A.,Eriksen, Jason L.,Annapragada, Ananth V.,Tanifum, Eric A.
(2021/11/10)
Highly diastereoselective spiro-cyclopropanation of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides
A highly diastereoselective spiro-cyclopropanation reaction of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides has been developedviabase-induced annulation. This efficient and simple protocol features simple operations, mild conditions and excellent functional group compatibility. A variety of structurally interesting spiro-cyclopropanes were prepared in excellent yields and diastereomeric ratios (up to 97% yield and 20?:?1 dr). Also, ring expansion of the cyclopropanation product to quickly deliver a complex indeno[1,2-c]pyridazine structure showcased an interesting application of this method.
Huang, Jie,Lee, Kevin,Ma, Ping,Sun, Shaofa,Wang, Gangqiang,Wang, Jian,Wu, Yang,Xing, Yalan
supporting information
p. 18776 - 18780
(2021/10/26)
Lewis Acid Triggered Vinylcyclopropane-Cyclopentene Rearrangement
We report a mild Lewis acid induced isomerization of donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse electron-withdrawing group(s) at the adjacent positions, into substituted cyclopentenes. We have found that 1,1,2-trisubstituted cy
Ivanova, Olga A.,Chagarovskiy, Alexey O.,Shumsky, Alexey N.,Krasnobrov, Vasiliy D.,Levina, Irina I.,Trushkov, Igor V.
p. 543 - 560
(2018/01/27)
Diastereoselective Synthesis of Functionalized Angularly-Fused Tetracycles via an Organocatalytic Quadruple Reaction Sequence
An efficient diastereoselective strategy to access complex structural tetracycles was described through an organocascade quadruple reaction sequence between (E)-2-(3-arylallylidene)-1H-indene-1,3(2H)-diones and β-keto esters. The reaction proceeded throug
Chang, Fu-Jie,Gurubrahamam, Ramani,Chen, Kwunmin
supporting information
p. 1277 - 1282
(2017/04/18)
A study on the reaction of 1,3-indandione with Schiff bases: Synthesis of new 1,3-indandiones with expected psychopharmacological and anticoagulant activity
Condensation of the title compound 1 with aldimines gave the 2-arylidene derivatives 3-9 instead of the expected Mannich bases 2. Compounds 10-11 were obtained from 1 and aldimines of α-ketoaldehydes. Isatin-anil (12) reacts with 1 to give 13. However, th
Afsah,Etman,Hamama,Sayed-Ahmed
p. 244 - 248
(2007/10/03)
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