- ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT
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Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.
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Paragraph 0030; 0091
(2013/03/28)
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- REACTIVITY OF UNSATURATED INDOLE DERIVATIVES TOWARDS ORGANOMETALLIC AND RADICAL POLYMERIZATION INITIATORS
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The ability of 3-allylindole (3-AIN) and 3-indolyl vinyl ketone (3-INVK) (prepared by literature methods) to polymerise has been investigated.After addition of pure 3-AIN to AlBu3i/TiCl3ARA catalyst, with molar ratios Al/Ti=3 and monomer/Ti=20, 3-AIN is recovered unchanged; on the contrary, if the monomer is previously complexed with an equimolar amount of either AlBu3i or TiCl3, the 3-(1-propyl)indole or a dimer are isolated, respectively.In every run no polymer formation was observed.In order to get information about interactions of the bimetallic Ziegler-Natta system with the indole nucleus, polymerisation of 4-methyl-1-pentene in the presence of the AlBu3i/TiCl3/indole system, using different values of indole/TiCl3 and indole/AlBu3i ratios, has also been carried out.Attempts to polymerise 3-INVK have been performed both by an anionic catalyst, such as ZnBu2i in tetrahydrofuran, and by a radical initiator, such as azobisisobutyronitrile in 2-propanol.In both cases no polymer was isolated, but when catalytic amounts of the initiators are employed, the monomer is recovered unchanged.When equimolar amounts of monomer to catalyst are used, 3-indolyl 4-methyl-1-pentyl ketone and 3-cyano-3-methyl-1-butyl 3-indolyl ketone are obtained in the anionic and radical polymerisation, respectively.Some hypotheses are put forward to explain the peculiar behaviour of vinyl monomers containing the indole nucleus.
- Pini, Dario
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p. 473 - 478
(2007/10/02)
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