24955-83-7

Usage

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx

InChI:InChI=1/C13H16N2O/c1-15(2)8-7-13(16)11-9-14-12-6-4-3-5-10(11)12/h3-6,9,14H,7-8H2,1-2H3

Upstream product

• 120-72-9 indole 
• 124-40-3 dimethyl amine 
• 625-36-5 2-chloropropionyl chloride 
• 50-00-0 formaldehyd 
• 703-80-0 3-acetylindole 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 101264-47-5 3-(α-Hydroxy-γ-dimethylaminopropyl)-indol 

Relevant academic research and scientific papers

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.

REACTIVITY OF UNSATURATED INDOLE DERIVATIVES TOWARDS ORGANOMETALLIC AND RADICAL POLYMERIZATION INITIATORS

The ability of 3-allylindole (3-AIN) and 3-indolyl vinyl ketone (3-INVK) (prepared by literature methods) to polymerise has been investigated.After addition of pure 3-AIN to AlBu3i/TiCl3ARA catalyst, with molar ratios Al/Ti=3 and monomer/Ti=20, 3-AIN is recovered unchanged; on the contrary, if the monomer is previously complexed with an equimolar amount of either AlBu3i or TiCl3, the 3-(1-propyl)indole or a dimer are isolated, respectively.In every run no polymer formation was observed.In order to get information about interactions of the bimetallic Ziegler-Natta system with the indole nucleus, polymerisation of 4-methyl-1-pentene in the presence of the AlBu3i/TiCl3/indole system, using different values of indole/TiCl3 and indole/AlBu3i ratios, has also been carried out.Attempts to polymerise 3-INVK have been performed both by an anionic catalyst, such as ZnBu2i in tetrahydrofuran, and by a radical initiator, such as azobisisobutyronitrile in 2-propanol.In both cases no polymer was isolated, but when catalytic amounts of the initiators are employed, the monomer is recovered unchanged.When equimolar amounts of monomer to catalyst are used, 3-indolyl 4-methyl-1-pentyl ketone and 3-cyano-3-methyl-1-butyl 3-indolyl ketone are obtained in the anionic and radical polymerisation, respectively.Some hypotheses are put forward to explain the peculiar behaviour of vinyl monomers containing the indole nucleus.