25067-30-5Relevant articles and documents
Preparation method of alpha-cyanoacrylate
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Paragraph 0054; 0055; 0056; 0057; 0058; 0059, (2019/06/11)
The invention relates to a preparation method of alpha-cyanoacrylate. The preparation method mainly includes the following steps that methyl cyanoacetate or ethyl cyanoacetate and formaldehyde are subjected to a condensation reaction to obtain a cyanoacrylate prepolymer; the cyanoacrylate prepolymer is cracked and rectified to obtain a methyl cyanoacrylate monomer or an ethyl cyanoacrylate monomer; and an anionic polymerization inhibitor, a free radical polymerization inhibitor, a catalyst and alcohol are added to the methyl cyanoacrylate monomer or the ethyl cyanoacrylate monomer for an esterexchange reaction, and the alpha-cyanoacrylate is obtained. According to the preparation method of the alpha-cyanoacrylate, the long-chain alpha-cyanoacrylate with the high content can be directly prepared, the depolymerization process under high-temperature and high-vacuum conditions is not required, the cost is lowered, the yield of products is increased, and the purity and stability of the products are improved.
PROCESS FOR PREPARING ELECTRON DEFICIENT OLEFINS
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Paragraph 0049; 0050, (2018/07/29)
This invention relates to a process for producing electron deficient olefins, such as 2-cyanoacrylates, using an acid catalyzed Knoevenagel condensation reaction.
Method for synthesizing cyanoacrylate
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Paragraph 0036; 0037, (2016/10/10)
The invention discloses a method for synthesizing cyanoacrylate. The method comprises steps as follows: cyanoacetic ester and dialkoxymethane are taken as raw materials and have a condensation reaction under the catalytic action of a catalyst, and a reaction mixture of a cyanoacrylate containing oligomer and byproduct alcohol is obtained; the byproduct alcohol and unreacted dialkoxymethane are separated, a stabilizer is added to the remaining reaction mixture, cracking distillation under the reduced pressure is performed, and a cyanoacrylate crude product is obtained; the crude product is purified, and a finished product, namely, cyanoacrylate is obtained. Solid paraformaldehyde is not used any more, the difficulty of solid feeding is reduced, a dehydration step is not required, a dehydrating agent is not required to be used, defects of a condensation polymerization process using solid paraformaldehyde and using a solvent for continuous dehydration in conventional cyanoacrylate synthesis are avoided, the reaction process is easier to control, the process is simple, the operability is high, the method is economical and reasonable, discharge of three wastes and pollution to the environment are greatly reduced, and the method has good social benefits.
1,1-DISUBSTITUTED ETHYLENE PROCESS
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Paragraph 0114, (2013/08/14)
New and improved processes for the production of 1,1-disubstituted ethylenes.
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones
Radi, Marco,Vallerini, Gian Paolo,Petrelli, Alessia,Vincetti, Paolo,Costantino, Gabriele
supporting information, p. 6905 - 6908 (2019/04/10)
A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been developed. The present method proved to be effective on a series of commercially available aldehydes, ketones and amines and could be profitably exploited in drug-discovery settings for the rapid identification of biologically relevant hit compounds.
ALTERNATIVE SYNTHESIS OF 1,1-SUBSTITUTED OLEFINS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS
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Page/Page column 7, (2012/12/13)
A three-stage method for synthesizing 1,1-disubstituted olefins is provided.
Imines and methods of preparing electron deficient olefins using such novel imines
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Page/Page column 16-17, (2011/11/13)
This invention relates to novel imines, some of which are in the form of ionic liquids, and a process for producing electron deficient olefins, such as 2-cyanoacrylates, using an imine, for instance such novel imines, many of which are in the form of an ionic liquid.
Method of preparing electron deficient olefins
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Page/Page column 7, (2010/06/11)
This invention relates to a process for producing electron deficient olefins, such as 2-cyanoacrylates, using an iminium salt.
Method of preparing electron deficient olefins
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Page/Page column 10-11, (2009/08/14)
This invention relates to processes for producing electron deficient olefins, such as 2-cyanoacrylates, using an iminium salt, and if desired contacting the reaction byproduct with alkali to generate an amine and separating that amine therefrom.
IMINIUM SALTS AND METHODS OF PREPARING ELECTRON DEFICIENT OLEFINS USING SUCH NOVEL IMINIUM SALTS
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Page/Page column 30-31, (2008/12/05)
This invention relates to novel iminium salts, which may be in the form of ionic liquids, and a process for producing electron deficient olefins, such as 2-cyanoacrylates, using such an iminium salt, for instance in the form of an ionic liquid.