cas 2510-36-3, 3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID | Articles data ｜lookchem

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2510-36-3

Articles about 2510-36-3Total 1 be found

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Setkina,Sokolov
(1968)
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Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study
In continuation of our drug discovery program on hyperlipidemia, a series of novel isoxazole-chenodeoxycholic acid hybrids were designed, synthesized and evaluated for their lipid-lowering effects. Preliminary screening of all the synthesized compounds was done by using a 3T3-L1 adipocyte model, in which the most active compound 16b could significantly reduce the lipid accumulation up to 30.5% at a nontoxic concentration 10 μM. Further mechanism studies revealed that 16b blocked lipid accumulation via activating FXR-SHP signaling pathway, efficiently down-regulated the expression of key lipogenesis regulator SREBP-1c.
Qiu, Rongmao,Luo, Guoshun,Li, Xinyu,Zheng, Fan,Li, Haolin,Zhang, Jin,You, Qidong,Xiang, Hua
supporting information
p. 2879 - 2884
(2018/07/25)

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Chemical Properties

Appearance/Colour :light beige powder
Melting Point: 141-145 °C(lit.)
Boiling Point: 301.826 °C at 760 mmHg
Flash Point:136.34 °C
Density: 1.276 g/cm³
Solubility:soluble in Methanol
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Vapor Pressure: 0.000455mmHg at 25°C
Refractive Index: 1.4890 (estimate)
PKA: 2.53±0.32(Predicted)
BRN: 115819
PSA: 63.33000
LogP: 0.98960

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